Complement C5

"Complement C5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.

Descriptor ID	D003182
MeSH Number(s)	D12.776.124.486.274.450
Concept/Terms	Complement C5 Complement C5 C5, Complement C5 Complement Complement, C5 Complement 5 Complement Component 5 Component 5, Complement Complement C5, Precursor Complement C5, Precursor C5, Precursor Complement Precursor Complement C5 Pro-C5 Pro C5 Pro-complement 5 Pro complement 5 Precursor C5 C5, Precursor

Below are MeSH descriptors whose meaning is more general than "Complement C5".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C5 [D12.776.124.486.274.450]

Below are MeSH descriptors whose meaning is related to "Complement C5".

Below are MeSH descriptors whose meaning is more specific than "Complement C5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C5" by people in this website by year, and whether "Complement C5" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2013	0	2	2
2014	0	1	1
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Complement C5" by people in Profiles.

Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.

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Frye AM, Hart TM, Tufts DM, Ram S, Diuk-Wasser MA, Kraiczy P, Blom AM, Lin YP. A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation. Ticks Tick Borne Dis. 2020 03; 11(2):101354.

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DeZern AE, Uknis M, Yuan X, Mukhina GL, Varela J, Saye J, Pu J, Brodsky RA. Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria. Exp Hematol. 2014 Oct; 42(10):857-61.e1.

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Samstad EO, Niyonzima N, Nymo S, Aune MH, Ryan L, Bakke SS, Lappeg?rd KT, Brekke OL, Lambris JD, Dam?s JK, Latz E, Mollnes TE, Espevik T. Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. J Immunol. 2014 Mar 15; 192(6):2837-45.

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Koenigs A, Hammerschmidt C, Jutras BL, Pogoryelov D, Barthel D, Skerka C, Kugelstadt D, Wallich R, Stevenson B, Zipfel PF, Kraiczy P. BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem. 2013 Aug 30; 288(35):25229-25243.

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Brookes C, Kuisma E, Alexander F, Allen L, Tipton T, Ram S, Gorringe A, Taylor S. Development of a large scale human complement source for use in bacterial immunoassays. J Immunol Methods. 2013 May 31; 391(1-2):39-49.

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Bomback AS, Smith RJ, Barile GR, Zhang Y, Heher EC, Herlitz L, Stokes MB, Markowitz GS, D'Agati VD, Canetta PA, Radhakrishnan J, Appel GB. Eculizumab for dense deposit disease and C3 glomerulonephritis. Clin J Am Soc Nephrol. 2012 May; 7(5):748-56.

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Klempner MS, Gallin JI, Balow JE, Van Kammen DP. The effect of hemodialysis and C5a des arg on neutrophil subpopulations. Blood. 1980 May; 55(5):777-83.

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Klempner MS, Gallin JI. Separation and functional characterization of human neutrophil subpopulations. Blood. 1978 Apr; 51(4):659-69.

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Finberg R, Barland P, Grayzel AI. Measurement of complement components in systemic lupus erythematosus by radial immunodiffusion. Am J Clin Pathol. 1977 Jan; 67(1):97-9.

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