Kidney Tubules, Proximal

"Kidney Tubules, Proximal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.

Descriptor ID	D007687
MeSH Number(s)	A05.810.453.736.560.570
Concept/Terms	Kidney Tubules, Proximal Kidney Tubules, Proximal Kidney Tubule, Proximal Proximal Kidney Tubules Tubule, Proximal Kidney Tubules, Proximal Kidney Proximal Renal Tubule Proximal Renal Tubules Renal Tubule, Proximal Renal Tubules, Proximal Tubule, Proximal Renal Tubules, Proximal Renal Proximal Kidney Tubule

Below are MeSH descriptors whose meaning is more general than "Kidney Tubules, Proximal".

Anatomy [A]
Urogenital System [A05]
Urinary Tract [A05.810]
Kidney [A05.810.453]
Nephrons [A05.810.453.736]
Kidney Tubules [A05.810.453.736.560]
Kidney Tubules, Proximal [A05.810.453.736.560.570]

Below are MeSH descriptors whose meaning is related to "Kidney Tubules, Proximal".

Below are MeSH descriptors whose meaning is more specific than "Kidney Tubules, Proximal".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Kidney Tubules, Proximal" by people in this website by year, and whether "Kidney Tubules, Proximal" was a major or minor topic of these publications.

Bar chart showing 18 publications over 14 distinct years, with a maximum of 2 publications in 2005 and 2018 and 2020 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2005	2	0	2
2006	0	1	1
2007	0	1	1
2009	1	0	1
2010	1	0	1
2014	1	0	1
2015	0	1	1
2016	1	0	1
2018	2	0	2
2019	1	0	1
2020	2	0	2
2021	1	1	2
2022	1	0	1

Below are the most recent publications written about "Kidney Tubules, Proximal" by people in Profiles.

Lidberg KA, Muthusamy S, Adil M, Mahadeo A, Yang J, Patel RS, Wang L, Bammler TK, Reichel J, Yeung CK, Himmelfarb J, Kelly EJ, Akilesh S. Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury. J Am Soc Nephrol. 2022 05; 33(5):949-965.

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Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 11 01; 11(1):21356.

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Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury. Am J Pathol. 2021 05; 191(5):817-828.

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Nieskens TTG, Persson M, Kelly EJ, Sj?gren AK. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug Metab Dispos. 2020 12; 48(12):1303-1311.

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Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 11; 444:152582.

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Teixeira DE, Peruchetti DB, Silva LS, Silva-Aguiar RP, Oquendo MB, Silva-Filho JL, Takiya CM, Leal-Cardoso JH, Pinheiro AAS, Caruso-Neves C. Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS One. 2019; 14(4):e0215871.

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Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. 2018 11; 46(11):1692-1702.

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Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system ALTEX. 2018; 35(4):504-515.

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Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016 09; 90(3):627-37.

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Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28.

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