Cytochrome P-450 CYP3A

"Cytochrome P-450 CYP3A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

Descriptor ID	D051544
MeSH Number(s)	D08.244.453.860.500 D08.811.682.662.582.353 D08.811.682.690.708.170.495.500 D12.776.422.220.453.860.500
Concept/Terms	Cytochrome P-450 CYP3A Cytochrome P-450 CYP3A Cytochrome P 450 CYP3A P-450 CYP3A, Cytochrome Cytochrome P-450IIIA Cytochrome P 450IIIA P-450IIIA, Cytochrome Erythromycin N-Demethylase Erythromycin N Demethylase N-Demethylase, Erythromycin CYP3A Cytochrome P450 3A P450 3A, Cytochrome Cytochrome P-450 CYP3A5 Cytochrome P-450 CYP3A5 Cytochrome P 450 CYP3A5 P-450 CYP3A5, Cytochrome CYP3A5 Cytochrome P450 3A5 3A5, Cytochrome P450 P450 3A5, Cytochrome Cytochrome P-450 CYP3A4 Cytochrome P-450 CYP3A4 Cytochrome P 450 CYP3A4 P-450 CYP3A4, Cytochrome Cytochrome P450 3A4 Taurochenodeoxycholate 6-alpha-Monooxygenase 6-alpha-Monooxygenase, Taurochenodeoxycholate Taurochenodeoxycholate 6 alpha Monooxygenase CYP3A4

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP3A".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 3 [D08.244.453.860]
Cytochrome P-450 CYP3A [D08.244.453.860.500]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxidoreductases Acting on CH-NH Group Donors [D08.811.682.662]
Oxidoreductases, N-Demethylating [D08.811.682.662.582]
Cytochrome P-450 CYP3A [D08.811.682.662.582.353]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 3 [D08.811.682.690.708.170.495]
Cytochrome P-450 CYP3A [D08.811.682.690.708.170.495.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 3 [D12.776.422.220.453.860]
Cytochrome P-450 CYP3A [D12.776.422.220.453.860.500]

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 CYP3A".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP3A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP3A" by people in this website by year, and whether "Cytochrome P-450 CYP3A" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 2007 and 2010 and 2012 and 2014 and 2017 and 2018 and 2019 and 2020 and 2021 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2010	0	1	1
2012	1	0	1
2014	0	1	1
2017	0	1	1
2018	1	0	1
2019	1	0	1
2020	1	0	1
2021	1	0	1
2024	0	1	1

Below are the most recent publications written about "Cytochrome P-450 CYP3A" by people in Profiles.

Arian C, O'Mahony E, MacDonald JW, Bammler TK, Donowitz M, Kelly EJ, Thummel KE. Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition. Drug Metab Dispos. 2025 Jan; 53(1):100002.

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Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021 02 25; 11(1):4722.

View in: PubMed
Sun W, Lirio RA, Schneider J, Aubrecht J, Kadali H, Baratta M, Gulati P, Suri A, Lin T, Vasudevan R, Rosario M. Assessment of Vedolizumab Disease-Drug-Drug Interaction Potential in Patients With Inflammatory Bowel Diseases. Clin Pharmacol Drug Dev. 2021 07; 10(7):734-747.

View in: PubMed
Shelton RC, Parikh SV, Law RA, Rothschild AJ, Thase ME, Dunlop BW, DeBattista C, Conway CR, Forester BP, Macaluso M, Hain DT, Aguilar AL, Brown K, Lewis DJ, Jablonski MR, Greden JF. Combinatorial Pharmacogenomic Algorithm is Predictive of Citalopram and Escitalopram Metabolism in Patients with Major Depressive Disorder. Psychiatry Res. 2020 08; 290:113017.

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Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. AAPS J. 2019 03 27; 21(3):45.

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Hamadeh IS, Zhang Q, Steuerwald N, Hamilton A, Druhan LJ, McSwain M, Diez Y, Rusin S, Han Y, Symanowski J, Gerber J, Grunwald MR, Ghosh N, Plesca D, Arnall J, Trivedi J, Avalos B, Copelan E, Patel JN. Effect of CYP3A4, CYP3A5, and ABCB1 Polymorphisms on Intravenous Tacrolimus Exposure and Adverse Events in Adult Allogeneic Stem Cell Transplant Patients. Biol Blood Marrow Transplant. 2019 04; 25(4):656-663.

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Li D, Du Y, Yuan X, Han X, Dong Z, Chen X, Wu H, Zhang J, Xu L, Han C, Zhang M, Xia Q. Hepatic hypoxia-inducible factors inhibit PPARa expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity. Free Radic Biol Med. 2017 09; 110:102-116.

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Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15; 92(4):690-700.

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Zhao C, Gao Q, Roberts AG, Shaffer SA, Doneanu CE, Xue S, Goodlett DR, Nelson SD, Atkins WM. Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). Biochemistry. 2012 Nov 27; 51(47):9488-500.

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Rhyee SH, Pedapati EV, Thompson J. Prolonged delirium after quetiapine overdose. Pediatr Emerg Care. 2010 Oct; 26(10):754-6.

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