Cytochrome P-450 CYP2E1

"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

Descriptor ID	D019392
MeSH Number(s)	D08.244.453.491.375 D08.811.682.662.582.338 D08.811.682.690.708.170.450.375 D12.776.422.220.453.491.375
Concept/Terms	Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP2E1 Cytochrome P 450 CYP2E1 Cytochrome P-450-J Cytochrome P 450 J 4-Nitrophenol-2-Hydroxylase 4 Nitrophenol 2 Hydroxylase Dimethylnitrosamine N-Demethylase Dimethylnitrosamine N Demethylase Cytochrome P450 2E1 N-Nitrosodimethylamine Demethylase N Nitrosodimethylamine Demethylase CYP 2E1 Cytochrome P-450 IIE1 Cytochrome P 450 IIE1 CYP IIE1 CYPIIE1 Cytochrome P-450 (ALC) CYP2E1

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 2 [D08.244.453.491]
Cytochrome P-450 CYP2E1 [D08.244.453.491.375]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxidoreductases Acting on CH-NH Group Donors [D08.811.682.662]
Oxidoreductases, N-Demethylating [D08.811.682.662.582]
Cytochrome P-450 CYP2E1 [D08.811.682.662.582.338]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
Cytochrome P-450 CYP2E1 [D08.811.682.690.708.170.450.375]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 2 [D12.776.422.220.453.491]
Cytochrome P-450 CYP2E1 [D12.776.422.220.453.491.375]

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in this website by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2008	0	2	2
2012	0	1	1
2016	0	1	1
2017	0	1	1
2021	0	1	1
2025	0	1	1

Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles.

Wang Y, Liu J, Zhu S, Hu S, Chen X, Mandon E, Tran NT, Zhang S, Qi Y, Ma H, He R, Cao Y, Su Q, Gallagher TL, Li Z, Zhou C, Tai PWL, Gao G, Xie J. miR-375 protects against acetaminophen-induced acute liver failure by orchestrating pharmacogene expression. Mol Ther. 2025 Oct 01; 33(10):4874-4888.

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Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada KI. Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques. Nat Commun. 2021 11 03; 12(1):6339.

View in: PubMed
Li D, Du Y, Yuan X, Han X, Dong Z, Chen X, Wu H, Zhang J, Xu L, Han C, Zhang M, Xia Q. Hepatic hypoxia-inducible factors inhibit PPARa expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity. Free Radic Biol Med. 2017 09; 110:102-116.

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Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Szabo G. Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease. World J Gastroenterol. 2016 Apr 28; 22(16):4091-108.

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Zhao C, Gao Q, Roberts AG, Shaffer SA, Doneanu CE, Xue S, Goodlett DR, Nelson SD, Atkins WM. Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). Biochemistry. 2012 Nov 27; 51(47):9488-500.

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Singh P, Shaffer SA, Scherl A, Holman C, Pfuetzner RA, Larson Freeman TJ, Miller SI, Hernandez P, Appel RD, Goodlett DR. Characterization of protein cross-links via mass spectrometry and an open-modification search strategy. Anal Chem. 2008 Nov 15; 80(22):8799-806.

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Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology. 2008 Oct; 48(4):1224-31.

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Gao Q, Doneanu CE, Shaffer SA, Adman ET, Goodlett DR, Nelson SD. Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis. J Biol Chem. 2006 Jul 21; 281(29):20404-17.

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