"Protease La" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.
| Descriptor ID |
D049070
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| MeSH Number(s) |
D08.811.277.040.013.500.032.099.750 D08.811.277.040.025.024.032.099.750 D08.811.277.656.149.099.750 D08.811.277.656.300.065.750 D12.776.157.025.750.032.099.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protease La".
Below are MeSH descriptors whose meaning is more specific than "Protease La".
This graph shows the total number of publications written about "Protease La" by people in this website by year, and whether "Protease La" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protease La" by people in Profiles.
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Yigit K, Chien P. Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus. J Bacteriol. 2024 07 25; 206(7):e0023724.
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Mahmoud SA, Aldikacti B, Chien P. ATP hydrolysis tunes specificity of a AAA+ protease. Cell Rep. 2022 09 20; 40(12):111405.
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Barros BB, Mahmoud SA, Chien P, Zeinert RD. Degradation of Lon in Caulobacter crescentus. J Bacteriol. 2020 12 07; 203(1).
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Zeinert RD, Baniasadi H, Tu BP, Chien P. The Lon Protease Links Nucleotide Metabolism with Proteotoxic Stress. Mol Cell. 2020 09 03; 79(5):758-767.e6.
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Joshi A, Mahmoud SA, Kim SK, Ogdahl JL, Lee VT, Chien P, Yildiz FH. c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae. PLoS Genet. 2020 06; 16(6):e1008897.
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Liu J, Zeinert R, Francis L, Chien P. Lon recognition of the replication initiator DnaA requires a bipartite degron. Mol Microbiol. 2019 01; 111(1):176-186.
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Vass RH, Zeinert RD, Chien P. Protease regulation and capacity during Caulobacter growth. Curr Opin Microbiol. 2016 12; 34:75-81.
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Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell Rep. 2015 Apr 14; 11(2):321-33.
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Mukherjee S, Bree AC, Liu J, Patrick JE, Chien P, Kearns DB. Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):250-5.
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Jonas K, Liu J, Chien P, Laub MT. Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 2013 Aug 01; 154(3):623-36.