DNA-(Apurinic or Apyrimidinic Site) Lyase
"DNA-(Apurinic or Apyrimidinic Site) Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
| Descriptor ID |
D043603
|
| MeSH Number(s) |
D08.811.074.750 D08.811.520.241.225
|
| Concept/Terms |
DNA-(Apurinic or Apyrimidinic Site) Lyase- DNA-(Apurinic or Apyrimidinic Site) Lyase
- AP Endonuclease
- Endonuclease, AP
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
- Apurine-Apyrimidine Endonuclease
- Apurine Apyrimidine Endonuclease
- Endonuclease, Apurine-Apyrimidine
- Apurinic DNA Endonuclease
- DNA Endonuclease, Apurinic
- Endonuclease, Apurinic DNA
- Apurinic Endonuclease
- Endonuclease, Apurinic
- DNA Lyase (Apurinic or Apyrimidinic)
- AP Lyase
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Below are MeSH descriptors whose meaning is more general than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
Below are MeSH descriptors whose meaning is more specific than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
This graph shows the total number of publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in this website by year, and whether "DNA-(Apurinic or Apyrimidinic Site) Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in Profiles.
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Jordano-Raya M, Schrader CE, Ariza RR, Rold?n-Arjona T, C?rdoba-Ca?ero D. Divergent evolution of opposite base specificity and single-stranded DNA activity in animal and plant AP endonucleases. Nucleic Acids Res. 2025 Jan 07; 53(1).
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Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nat Methods. 2018 06; 15(6):433-436.
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Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. J Immunol. 2014 Jul 15; 193(2):931-9.
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Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y, Schrader CE. Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9217-22.
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Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-1189.
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Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase d catalytic subunit gene, POLD1. J Biol Chem. 2012 Aug 24; 287(35):29801-14.
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Guikema JE, Gerstein RM, Linehan EK, Cloherty EK, Evan-Browning E, Tsuchimoto D, Nakabeppu Y, Schrader CE. Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. J Immunol. 2011 Feb 15; 186(4):1943-50.
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Pei DS, Yang XJ, Liu W, Guikema JE, Schrader CE, Strauss PR. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic Acids Res. 2011 Apr; 39(8):3156-65.
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Guikema JE, Stavnezer J, Schrader CE. The role of Apex2 in class-switch recombination of immunoglobulin genes. Int Immunol. 2010 Mar; 22(3):213; author reply 213-4.
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Schrader CE, Guikema JE, Wu X, Stavnezer J. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):645-52.