Plasminogen Activator Inhibitor 1

"Plasminogen Activator Inhibitor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.

Descriptor ID	D017395
MeSH Number(s)	D12.644.861.695.500 D12.776.124.125.640 D12.776.872.695.500 D23.119.832.500
Concept/Terms	Plasminogen Activator Inhibitor 1 Plasminogen Activator Inhibitor 1 PAI-1 Serpin E1 E1, Serpin SERPINE1 Protein Protein, SERPINE1 Type 1 Plasminogen Activator Inhibitor

Below are MeSH descriptors whose meaning is more general than "Plasminogen Activator Inhibitor 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Serpins [D12.644.861]
Plasminogen Inactivators [D12.644.861.695]
Plasminogen Activator Inhibitor 1 [D12.644.861.695.500]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
Plasminogen Activator Inhibitor 1 [D12.776.124.125.640]
Serpins [D12.776.872]
Plasminogen Inactivators [D12.776.872.695]
Plasminogen Activator Inhibitor 1 [D12.776.872.695.500]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
Plasminogen Inactivators [D23.119.832]
Plasminogen Activator Inhibitor 1 [D23.119.832.500]

Below are MeSH descriptors whose meaning is more specific than "Plasminogen Activator Inhibitor 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Plasminogen Activator Inhibitor 1" by people in this website by year, and whether "Plasminogen Activator Inhibitor 1" was a major or minor topic of these publications.

Bar chart showing 13 publications over 10 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	1	0	1
2000	0	1	1
2002	0	1	1
2006	1	0	1
2007	0	2	2
2008	0	1	1
2009	0	1	1
2010	1	0	1
2012	1	2	3

Below are the most recent publications written about "Plasminogen Activator Inhibitor 1" by people in Profiles.

Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF. Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. J Crohns Colitis. 2013 Jun; 7(5):403-11.

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Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9.

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Esposito AJ, Heydrick SJ, Cassidy MR, Gallant J, Stucchi AF, Becker JM. Substance P is an early mediator of peritoneal fibrinolytic pathway genes and promotes intra-abdominal adhesion formation. J Surg Res. 2013 May 01; 181(1):25-31.

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Laine O, Joutsi-Korhonen L, Mäkelä S, Mikkelsson J, Pessi T, Tuomisto S, Huhtala H, Libraty D, Vaheri A, Karhunen P, Mustonen J. Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. Thromb Res. 2012 May; 129(5):611-5.

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Velagaleti RS, Gona P, Larson MG, Wang TJ, Levy D, Benjamin EJ, Selhub J, Jacques PF, Meigs JB, Tofler GH, Vasan RS. Multimarker approach for the prediction of heart failure incidence in the community. Circulation. 2010 Oct 26; 122(17):1700-6.

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Goddeau RP, Caplan LR, Alhazzani AA. Intraparenchymal hemorrhage in a patient with osteogenesis imperfecta and plasminogen activator inhibitor-1 deficiency. Arch Neurol. 2010 Feb; 67(2):236-8.

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Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, Sutton-Tyrrell K. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol. 2009 Dec 15; 54(25):2366-73.

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Velagaleti RS, Gona P, Levy D, Aragam J, Larson MG, Tofler GH, Lieb W, Wang TJ, Benjamin EJ, Vasan RS. Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation. 2008 Nov 25; 118(22):2252-8, 5p following 2258.

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Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23.

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Beaulieu LM, Whitley BR, Wiesner TF, Rehault SM, Palmieri D, Elkahloun AG, Church FC. Breast cancer and metabolic syndrome linked through the plasminogen activator inhibitor-1 cycle. Bioessays. 2007 Oct; 29(10):1029-38.

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