Platelet Factor 4

"Platelet Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

Descriptor ID	D010978
MeSH Number(s)	D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900
Concept/Terms	Platelet Factor 4 Platelet Factor 4 Chemokine CXCL4 CXCL4, Chemokine PF4 (Platelet Factor 4) gamma-Thromboglobulin gamma Thromboglobulin Heparin Neutralizing Protein Antiheparin Factor CXCL4 Chemokine Chemokine, CXCL4

Below are MeSH descriptors whose meaning is more general than "Platelet Factor 4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CXC [D12.644.276.374.200.120]
Platelet Factor 4 [D12.644.276.374.200.120.900]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
Platelet Factor 4 [D12.776.124.125.720]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CXC [D12.776.467.374.200.120]
Platelet Factor 4 [D12.776.467.374.200.120.900]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
Platelet Factor 4 [D23.119.940]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CXC [D23.125.300.120]
Platelet Factor 4 [D23.125.300.120.900]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CXC [D23.469.200.120]
Platelet Factor 4 [D23.469.200.120.900]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CXC [D23.529.374.200.120]
Platelet Factor 4 [D23.529.374.200.120.900]

Below are MeSH descriptors whose meaning is more specific than "Platelet Factor 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and whether "Platelet Factor 4" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2005 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2005	2	0	2
2007	1	0	1
2009	1	0	1
2016	0	1	1
2017	0	1	1
2020	1	0	1
2023	1	0	1
2024	1	1	2

Below are the most recent publications written about "Platelet Factor 4" by people in Profiles.

Nguyen SN, Le SH, Ivanov DG, Ivetic N, Nazy I, Kaltashov IA. Structural Characterization of a Pathogenic Antibody Underlying Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). Anal Chem. 2024 04 23; 96(16):6209-6217.

View in: PubMed
Yang Y, Du Y, Ivanov D, Niu C, Clare R, Smith JW, Nazy I, Kaltashov IA. Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4. Commun Biol. 2024 03 11; 7(1):308.

View in: PubMed
?akan E, Ah Kioon MD, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Vega Loza A, Du Y, Schickel JN, Boeckers JM, Yang C, Baldo A, Ivashkiv LB, Young RM, Staudt LM, Moody KL, N?ndel K, Marshak-Rothstein A, van der Made CI, Hoischen A, Hayward A, Rossato M, Radstake TRDJ, Cunningham-Rundles C, Ryu C, Herzog EL, Barrat FJ, Meffre E. TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance. J Exp Med. 2023 12 04; 220(12).

View in: PubMed
Niu C, Yang Y, Huynh A, Nazy I, Kaltashov IA. Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly. Biophys J. 2020 10 06; 119(7):1371-1379.

View in: PubMed
Raschke RA, Gallo T, Curry SC, Whiting T, Padilla-Jones A, Warkentin TE, Puri A. Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia. J Thromb Haemost. 2017 08; 15(8):1640-1645.

View in: PubMed
Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501.

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Gluckman TJ, Segal JB, Schulman SP, Shapiro EP, Kickler TS, Prechel MM, Conte JV, Walenga JM, Shafique I, Rade JJ. Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost. 2009 Sep; 7(9):1457-64.

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Everett BM, Yeh R, Foo SY, Criss D, Van Cott EM, Laposata M, Avery EG, Hoffman WD, Walker J, Torchiana D, Jang IK. Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery. Ann Thorac Surg. 2007 Feb; 83(2):592-7.

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Gluckman TJ, Segal JB, Fredde NL, Saland KE, Jani JT, Walenga JM, Prechel MM, Citro KM, Zidar DA, Fox E, Schulman SP, Kickler TS, Rade JJ. Incidence of antiplatelet factor 4/heparin antibody induction in patients undergoing percutaneous coronary revascularization. Am J Cardiol. 2005 Mar 15; 95(6):744-7.

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Benny O, Duvshani-Eshet M, Cargioli T, Bello L, Bikfalvi A, Carroll RS, Machluf M. Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):768-76.

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