Chemokine CXCL12

"Chemokine CXCL12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.

Descriptor ID	D054377
MeSH Number(s)	D12.644.276.374.200.120.600 D12.776.467.374.200.120.600 D23.125.300.120.600 D23.469.200.120.600 D23.529.374.200.120.600
Concept/Terms	Chemokine CXCL12 Chemokine CXCL12 CXCL12, Chemokine Stromal Cell-Derived Factor 1 Stromal Cell Derived Factor 1 CXCL12 Chemokine Chemokine, CXCL12 Chemokine (C-X-C Motif) Ligand 12 Pre-B-Cell Growth-Stimulating Factor Growth-Stimulating Factor, Pre-B-Cell Pre B Cell Growth Stimulating Factor Stromal Cell-Derived Factor-1alpha Stromal Cell-Derived Factor-1alpha Stromal Cell Derived Factor 1alpha SDF-1alpha SDF 1alpha Stromal Cell-Derived Factor-1beta Stromal Cell-Derived Factor-1beta Cell-Derived Factor-1beta, Stromal Stromal Cell Derived Factor 1beta SDF-1beta SDF 1beta SDF1-3'A SDF1-3'A SDF1 3'A

Below are MeSH descriptors whose meaning is more general than "Chemokine CXCL12".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CXC [D12.644.276.374.200.120]
Chemokine CXCL12 [D12.644.276.374.200.120.600]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CXC [D12.776.467.374.200.120]
Chemokine CXCL12 [D12.776.467.374.200.120.600]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CXC [D23.125.300.120]
Chemokine CXCL12 [D23.125.300.120.600]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CXC [D23.469.200.120]
Chemokine CXCL12 [D23.469.200.120.600]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CXC [D23.529.374.200.120]
Chemokine CXCL12 [D23.529.374.200.120.600]

Below are MeSH descriptors whose meaning is related to "Chemokine CXCL12".

Below are MeSH descriptors whose meaning is more specific than "Chemokine CXCL12".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemokine CXCL12" by people in this website by year, and whether "Chemokine CXCL12" was a major or minor topic of these publications.

Bar chart showing 14 publications over 12 distinct years, with a maximum of 2 publications in 2011 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	0	1	1
2002	0	1	1
2008	1	0	1
2011	1	1	2
2012	1	0	1
2013	0	2	2
2014	0	1	1
2015	1	0	1
2016	1	0	1
2022	0	1	1
2025	1	0	1

Below are the most recent publications written about "Chemokine CXCL12" by people in Profiles.

Agueda-Oyarzabal M, Isidor MS, Plucinska K, Ingerslev LR, Dmytriyeva O, Petersen PSS, Laftih S, Pontoppidan AB, Henningsen JB, Rupar K, Brown EL, Schwartz TW, Barr?s R, Gerhart-Hines Z, Sch?ele CC, Emanuelli B. Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine. Mol Metab. 2025 Mar; 93:102102.

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Pillon NJ, Smith JAB, Alm PS, Chibalin AV, Alhusen J, Arner E, Carninci P, Fritz T, Otten J, Olsson T, van Doorslaer de Ten Ryen S, Deldicque L, Caidahl K, Wallberg-Henriksson H, Krook A, Zierath JR. Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. Sci Adv. 2022 09 09; 8(36):eabo3192.

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Addington CP, Dharmawaj S, Heffernan JM, Sirianni RW, Stabenfeldt SE. Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1a. Matrix Biol. 2017 07; 60-61:206-216.

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Addington CP, Heffernan JM, Millar-Haskell CS, Tucker EW, Sirianni RW, Stabenfeldt SE. Enhancing neural stem cell response to SDF-1a gradients through hyaluronic acid-laminin hydrogels. Biomaterials. 2015 Dec; 72:11-9.

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Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23.

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Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. Eur Heart J. 2014 Aug 14; 35(31):2115-22.

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Donnelly JM, Chawla A, Houghton J, Zavros Y. Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PLoS One. 2013; 8(9):e75225.

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Bam R, Ling W, Khan S, Pennisi A, Venkateshaiah SU, Li X, van Rhee F, Usmani S, Barlogie B, Shaughnessy J, Epstein J, Yaccoby S. Role of Bruton's tyrosine kinase in myeloma cell migration and induction of bone disease. Am J Hematol. 2013 Jun; 88(6):463-71.

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Park JM, Munoz JL, Won BW, Bliss SA, Greco SJ, Patel SA, Kandouz M, Rameshwar P. Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells. Cancer Lett. 2013 Apr 30; 331(1):84-91.

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Allen IC, Wilson JE, Schneider M, Lich JD, Roberts RA, Arthur JC, Woodford RM, Davis BK, Uronis JM, Herfarth HH, Jobin C, Rogers AB, Ting JP. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-?B signaling. Immunity. 2012 May 25; 36(5):742-54.

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