Platelet Activating Factor
"Platelet Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
| Descriptor ID |
D010972
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| MeSH Number(s) |
D02.033.100.291.211.500 D02.092.063.291.211.500 D02.092.877.883.333.710 D02.675.276.232.710 D10.570.755.375.760.400.985.910 D23.119.865 D23.469.050.600
|
| Concept/Terms |
Platelet Activating Factor- Platelet Activating Factor
- Factor, Platelet Activating
- Phosphorylcholine, Acetyl Glyceryl Ether
- Platelet Aggregating Factor
- Aggregating Factor, Platelet
- Platelet Aggregation Enhancing Factor
- AGEPC
- Thrombocyte Aggregating Activity
- 1-Alkyl-2-acetyl-sn-glycerophosphocholine
- 1 Alkyl 2 acetyl sn glycerophosphocholine
- Acetyl Glyceryl Ether Phosphorylcholine
- PAF-Acether
- PAF Acether
- Platelet-Activating Substance
- Platelet Activating Substance
|
Below are MeSH descriptors whose meaning is more general than "Platelet Activating Factor".
Below are MeSH descriptors whose meaning is more specific than "Platelet Activating Factor".
This graph shows the total number of publications written about "Platelet Activating Factor" by people in this website by year, and whether "Platelet Activating Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Platelet Activating Factor" by people in Profiles.
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Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, McKinnon KP, Beutler B, Ting JP. Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR. J Exp Med. 2019 12 02; 216(12):2838-2853.
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Frelinger AL, Michelson AD, Wiviott SD, Trenk D, Neumann FJ, Miller DL, Jakubowski JA, Costigan TM, McCabe CH, Antman EM, Braunwald E. Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. Thromb Haemost. 2011 Aug; 106(2):219-26.
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Knapp S, von Aulock S, Leendertse M, Haslinger I, Draing C, Golenbock DT, van der Poll T. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol. 2008 Mar 01; 180(5):3478-84.
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Strait RT, Morris SC, Smiley K, Urban JF, Finkelman FD. IL-4 exacerbates anaphylaxis. J Immunol. 2003 Apr 01; 170(7):3835-42.
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Weber C, Erl W, Weber KS, Weber PC. Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions. Clin Chem Lab Med. 1999 Mar; 37(3):243-51.
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Vittimberga FJ, Foley DP, Perugini RA, McDade TP, Callery MP. Endotoxin fails to stimulate inositol triphosphate production in macrophages. Int J Surg Investig. 1999; 1(3):229-35.
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Weber C, Kruse HJ, Sellmayer A, Erl W, Weber PC. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. Biochem Biophys Res Commun. 1993 Sep 15; 195(2):874-80.
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Weber C, Aepfelbacher M, Haag H, Ziegler-Heitbrock HW, Weber PC. Tumor necrosis factor induces enhanced responses to platelet-activating factor and differentiation in human monocytic Mono Mac 6 cells. Eur J Immunol. 1993 Apr; 23(4):852-9.
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Aepfelbacher M, Ziegler-Heitbrock HW, Lux I, Weber PC. Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells. J Immunol. 1992 Apr 01; 148(7):2186-93.
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Weber C, Aepfelbacher M, Lux I, Zimmer B, Weber PC. Docosahexaenoic acid inhibits PAF and LTD4 stimulated [Ca2+]i-increase in differentiated monocytic U937 cells. Biochim Biophys Acta. 1991 Dec 03; 1133(1):38-45.