"Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
| Descriptor ID |
D011516
|
| MeSH Number(s) |
D08.622.709 D12.776.124.125.800 D23.119.945
|
| Concept/Terms |
Prothrombin- Prothrombin
- Factor II
- Blood Coagulation Factor II
- Differentiation Reversal Factor
- Factor, Differentiation Reversal
- Coagulation Factor II
- Factor II, Coagulation
- II, Coagulation Factor
|
Below are MeSH descriptors whose meaning is more general than "Prothrombin".
Below are MeSH descriptors whose meaning is more specific than "Prothrombin".
This graph shows the total number of publications written about "Prothrombin" by people in this website by year, and whether "Prothrombin" was a major or minor topic of these publications.
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Below are the most recent publications written about "Prothrombin" by people in Profiles.
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Hirbawi J, Bukys MA, Barhoover MA, Erdogan E, Kalafatis M. Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase. Biochemistry. 2008 Jul 29; 47(30):7963-74.
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Tran M, Spencer FA. Thromboepidemiology: identifying patients with heritable risk for thrombin-mediated thromboembolic events. Am Heart J. 2005 Jan; 149(1 Suppl):S9-18.
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D?nmez Y, Kanadasi M, Tanriverdi K, Demir M, Demirtas M, Cayli M, Alhan C, Baslamisli F. Prothrombin 20210GA and factor V Leiden mutations in patients less than 55 years old with myocardial infarction. Jpn Heart J. 2004 May; 45(3):505-12.
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Liu L, Freedman J, Hornstein A, Fenton JW, Ofosu FA. Thrombin binding to platelets and their activation in plasma. Br J Haematol. 1994 Nov; 88(3):592-600.
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Hartmann K, Rauch J, Urban J, Parczyk K, Diel P, Pilarsky C, Appel D, Haase W, Mann K, Weller A, et al. Molecular cloning of gp 80, a glycoprotein complex secreted by kidney cells in vitro and in vivo. A link to the reproductive system and to the complement cascade. J Biol Chem. 1991 May 25; 266(15):9924-31.