 Guanine
"Guanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
No definition found.
| Descriptor ID |
D006147
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| MeSH Number(s) |
D03.438.759.758.399.454
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Guanine".
Below are MeSH descriptors whose meaning is more specific than "Guanine".
This graph shows the total number of publications written about "Guanine" by people in this website by year, and whether "Guanine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 | | 1986 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 | | 1993 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Guanine" by people in Profiles.
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Barnes MH, Butler MM, Wright GE, Brown NC. Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE. Infect Disord Drug Targets. 2012 Oct; 12(5):327-31.
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Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4197-202.
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Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW. N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro Oncol. 2011 May; 13(5):471-86.
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Wang Y, Liu X, Zhang Y, Liu G, Rusckowski M, Hnatowich DJ. Nonspecific cellular accumulation of 99mTc-labeled oligonucleotides in culture is influenced by their guanine content. Nucl Med Biol. 2007 Jan; 34(1):47-54.
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Jurk M, Kritzler A, Debelak H, Vollmer J, Krieg AM, Uhlmann E. Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like receptor 9 agonists. ChemMedChem. 2006 Sep; 1(9):1007-14.
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Manikowski A, Verri A, Lossani A, Gebhardt BM, Gambino J, Focher F, Spadari S, Wright GE. Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem. 2005 Jun 2; 48(11):3919-29.
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Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):729-32.
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Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem. 2004 Jul 5; 5(7):1010-2.
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Wyrzykowski J, Volkert MR. The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions. J Bacteriol. 2003 Mar; 185(5):1701-4.
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Hoffman VF, Skiest DJ. Therapeutic developments in cytomegalovirus retinitis. Expert Opin Investig Drugs. 2000 Feb; 9(2):207-20.
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