Hedgehog Proteins

"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.

Descriptor ID	D053823
MeSH Number(s)	D12.644.276.671 D12.776.467.671 D23.529.671
Concept/Terms	Hedgehog Proteins Hedgehog Proteins Sonic Hedgehog Protein Sonic Hedgehog Protein Hedgehog Protein, Sonic Hedgehog Protein, Vertebrate Hedgehog Protein, Vertebrate Vertebrate Hedgehog Protein Indian Hedgehog Protein Indian Hedgehog Protein Hedgehog Protein, Indian Banded Hedgehog Protein Banded Hedgehog Protein Hedgehog Protein, Banded Desert Hedgehog Protein Desert Hedgehog Protein Hedgehog Protein, Desert

Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Hedgehog Proteins [D12.644.276.671]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Hedgehog Proteins [D12.776.467.671]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Hedgehog Proteins [D23.529.671]

Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.

Bar chart showing 103 publications over 27 distinct years, with a maximum of 9 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	1	1
1999	0	2	2
2000	0	1	1
2001	0	1	1
2002	0	4	4
2003	0	5	5
2004	0	4	4
2005	0	6	6
2006	2	5	7
2007	7	1	8
2008	4	2	6
2009	5	0	5
2010	5	4	9
2011	5	0	5
2012	4	0	4
2013	6	1	7
2014	4	2	6
2015	2	0	2
2016	1	0	1
2017	2	2	4
2018	3	0	3
2020	3	1	4
2021	2	1	3
2022	1	1	2
2023	1	0	1
2025	0	1	1

Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.

Banday S, Mishra AK, Rashid R, Ye T, Ali A, Li J, Yustein JT, Kelliher MA, Zhu LJ, Deibler SK, Malonia SK, Green MR. The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Nat Commun. 2025 Feb 02; 16(1):1267.

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Suthar KP, Bergmann A. Something new under the sun: caspases promote cell survival under moderate heat stress. EMBO Rep. 2023 06 05; 24(6):e57276.

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Lv B, Zhang XO, Pazour GJ. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. J Cell Sci. 2022 08 15; 135(16).

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George J, Chen Y, Abdelfattah N, Yamamoto K, Gallup TD, Adamson SI, Rybinski B, Srivastava A, Kumar P, Lee MG, Baskin DS, Jiang W, Choi JM, Flavahan W, Chuang JH, Kim BY, Xu J, Jung SY, Yun K. Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors. Cancer Res Commun. 2022 06; 2(6):402-416.

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Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, Marquez SJ, White TE, Khan AG, Lorenz IC, Shim JH, Lee FS, Xu R, Greenblatt MB. SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nat Commun. 2021 07 29; 12(1):4611.

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Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, H?ttenhain R, Manglik A, Myers BR. Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 04; 19(4):e3001191.

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Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 03; 97:40-57.

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Male I, Ozacar AT, Fagan RR, Loring MD, Shen MC, Pace VA, Devine CA, Lawson GE, Lutservitz A, Karlstrom RO. Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus. eNeuro. 2020 Nov-Dec; 7(6).

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Yao H, Sun L, Li J, Zhou X, Li R, Shao R, Zhang Y, Li L. A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells. Int J Nanomedicine. 2020; 15:7013-7034.

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Navon D, Male I, Tetrault ER, Aaronson B, Karlstrom RO, Albertson RC. Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity in teleosts. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19321-19327.

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