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Paul R Thompson PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    McMaster University, Hamilton, ON, CanadaBSBiochemistry
    McMaster University, Hamilton, ON, CanadaPHDBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kenny EF, Herzig A, Krüger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Von Bernuth H, Zychlinsky A. Diverse stimuli engage different neutrophil extracellular trap pathways. Elife. 2017 Jun 02; 6. PMID: 28574339.
      View in: PubMed
    2. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. BMC Cancer. 2017 May 26; 17(1):378. PMID: 28549415.
      View in: PubMed
    3. Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR. Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. ACS Chem Biol. 2017 May 09. PMID: 28485572.
      View in: PubMed
    4. Muth A, Subramanian V, Beaumont E, Nagar M, Kerry P, McEwan P, Srinath H, Clancy KW, Parelkar SS, Thompson PR. Development of a selective inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Mar 22. PMID: 28328217.
      View in: PubMed
    5. Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Sci Rep. 2016 Dec 08; 6:38727. PMID: 27929094.
      View in: PubMed
    6. Fuhrmann J, Subramanian V, Kojetin DJ, Thompson PR. Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation. Cell Chem Biol. 2016 Aug 18; 23(8):967-977. PMID: 27524296.
      View in: PubMed
    7. Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ. Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses. Sci Rep. 2016 May 23; 6:26430. PMID: 27210478.
      View in: PubMed
    8. Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv. 2016 Feb; 2(2):e1501257. PMID: 26989780.
      View in: PubMed
    9. Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD. Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland. PLoS One. 2016; 11(1):e0147503. PMID: 26799659.
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    10. Fuhrmann J, Thompson PR. Protein Arginine Methylation and Citrullination in Epigenetic Regulation. ACS Chem Biol. 2016 Mar 18; 11(3):654-68. PMID: 26686581.
      View in: PubMed
    11. Witalison EE, Cui X, Causey CP, Thompson PR, Hofseth LJ. Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget. 2015 Nov 03; 6(34):36053-62. PMID: 26440311.
      View in: PubMed
    12. Clancy KW, Weerapana E, Thompson PR. Detection and identification of protein citrullination in complex biological systems. Curr Opin Chem Biol. 2016 Feb; 30:1-6. PMID: 26517730.
      View in: PubMed
    13. Fuhrmann J, Subramanian V, Thompson PR. Synthesis and Use of a Phosphonate Amidine to Generate an Anti-Phosphoarginine-Specific Antibody. Angew Chem Int Ed Engl. 2015 Dec 1; 54(49):14715-8. PMID: 26458230.
      View in: PubMed
    14. Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR. Chemical Proteomic Platform To Identify Citrullinated Proteins. ACS Chem Biol. 2015 Nov 20; 10(11):2520-8. PMID: 26360112.
      View in: PubMed
    15. Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S. A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. J Extracell Vesicles. 2015; 4:26192. PMID: 26095379.
      View in: PubMed
    16. Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA. Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells. J Vis Exp. 2015 May 20; (99):e52727. PMID: 26067809.
      View in: PubMed
    17. Fuhrmann J, Clancy KW, Thompson PR. Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev. 2015 Jun 10; 115(11):5413-61. PMID: 25970731.
      View in: PubMed
    18. Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. J Pharmacol Exp Ther. 2015 Apr; 353(1):64-70. PMID: 25635139.
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    19. Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem Biol. 2015 Apr 17; 10(4):1043-53. PMID: 25621824.
      View in: PubMed
    20. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar; 11(3):189-91. PMID: 25622091; PMCID: PMC4397581.
    21. Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015 Feb 12; 58(3):1337-44. PMID: 25559347.
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    22. Witalison EE, Thompson PR, Hofseth LJ. Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Curr Drug Targets. 2015; 16(7):700-10. PMID: 25642720.
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    23. Wang M, Fuhrmann J, Thompson PR. Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion. Biochemistry. 2014 Dec 23; 53(50):7884-92. PMID: 25485739.
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    24. Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis Rheumatol. 2014 Sep; 66(9):2532-44. PMID: 24838349.
      View in: PubMed
    25. Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec; 74(12):2199-206. PMID: 25104775.
      View in: PubMed
    26. Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry. 2014 Jul 15; 53(27):4426-33. PMID: 24989433.
      View in: PubMed
    27. Slade DJ, Horibata S, Coonrod SA, Thompson PR. A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. Bioessays. 2014 Aug; 36(8):736-40. PMID: 24889365.
      View in: PubMed
    28. Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G. Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. J Neurochem. 2014 Aug; 130(4):555-62. PMID: 24762056.
      View in: PubMed
    29. Slade DJ, Subramanian V, Thompson PR. Pluripotency: citrullination unravels stem cells. Nat Chem Biol. 2014 May; 10(5):327-8. PMID: 24743255.
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    30. U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P. Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway. Biochim Biophys Acta. 2014 Jun; 1843(6):1162-71. PMID: 24607566.
      View in: PubMed
    31. Slade DJ, Subramanian V, Fuhrmann J, Thompson PR. Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers. 2014 Feb; 101(2):133-43. PMID: 23576281.
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    32. Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. ACS Chem Biol. 2014 Apr 18; 9(4):913-21. PMID: 24467619.
      View in: PubMed
    33. Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ. Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res. 2014 Mar 14; 114(6):947-56. PMID: 24425713.
      View in: PubMed
    34. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15; 22(4):1362-9. PMID: 24440480.
      View in: PubMed
    35. Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. ACS Chem Biol. 2014 Mar 21; 9(3):649-55. PMID: 24358983.
      View in: PubMed
    36. Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. ACS Chem Biol. 2014 Feb 21; 9(2):433-42. PMID: 24274060.
      View in: PubMed
    37. Dillon MB, Rust HL, Thompson PR, Mowen KA. Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. J Biol Chem. 2013 Sep 27; 288(39):27872-80. PMID: 23946480.
      View in: PubMed
    38. Wang M, Xu RM, Thompson PR. Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. Biochemistry. 2013 Aug 13; 52(32):5430-40. PMID: 23866019.
      View in: PubMed
    39. Fuhrmann J, Subramanian V, Thompson PR. Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor. ACS Chem Biol. 2013 Sep 20; 8(9):2024-32. PMID: 23838530.
      View in: PubMed
    40. Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest. 2013 Jul; 123(7):2981-93. PMID: 23722903.
      View in: PubMed
    41. Bicker KL, Thompson PR. The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers. 2013 Feb; 99(2):155-63. PMID: 23175390.
      View in: PubMed
    42. Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ. The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One. 2013; 8(1):e53791. PMID: 23308284.
      View in: PubMed
    43. McElwee JL, Mohanan S, Griffith OL, Breuer HC, Anguish LJ, Cherrington BD, Palmer AM, Howe LR, Subramanian V, Causey CP, Thompson PR, Gray JW, Coonrod SA. Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. BMC Cancer. 2012 Oct 30; 12:500. PMID: 23110523.
      View in: PubMed
    44. Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26; 3(12):1081-1085. PMID: 23420624.
      View in: PubMed
    45. Bicker KL, Subramanian V, Chumanevich AA, Hofseth LJ, Thompson PR. Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination. J Am Chem Soc. 2012 Oct 17; 134(41):17015-8. PMID: 23030787.
      View in: PubMed
    46. Mohanan S, Cherrington BD, Horibata S, McElwee JL, Thompson PR, Coonrod SA. Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis. Biochem Res Int. 2012; 2012:895343. PMID: 23019525.
      View in: PubMed
    47. Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13331-6. PMID: 22853951.
      View in: PubMed
    48. Kan R, Jin M, Subramanian V, Causey CP, Thompson PR, Coonrod SA. Potential role for PADI-mediated histone citrullination in preimplantation development. BMC Dev Biol. 2012 Jun 19; 12:19. PMID: 22712504.
      View in: PubMed
    49. Mohamed BM, Verma NK, Davies AM, McGowan A, Crosbie-Staunton K, Prina-Mello A, Kelleher D, Botting CH, Causey CP, Thompson PR, Pruijn GJ, Kisin ER, Tkach AV, Shvedova AA, Volkov Y. Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (Lond). 2012 Aug; 7(8):1181-95. PMID: 22625207.
      View in: PubMed
    50. Lewallen DM, Steckler CJ, Knuckley B, Chalmers MJ, Thompson PR. Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates. Mol Biosyst. 2012 Jun; 8(6):1701-6. PMID: 22456874.
      View in: PubMed
    51. Obianyo O, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J Biol Chem. 2012 Feb 17; 287(8):6062-71. PMID: 22219200.
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    52. Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20; 7(1):160-5. PMID: 22004374.
      View in: PubMed
    53. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem. 2011 Oct 13; 54(19):6919-35. PMID: 21882827.
      View in: PubMed
    54. Obianyo O, Causey CP, Jones JE, Thompson PR. Activity-based protein profiling of protein arginine methyltransferase 1. ACS Chem Biol. 2011 Oct 21; 6(10):1127-35. PMID: 21838253.
      View in: PubMed
    55. Rust HL, Thompson PR. Kinase consensus sequences: a breeding ground for crosstalk. ACS Chem Biol. 2011 Sep 16; 6(9):881-92. PMID: 21721511.
      View in: PubMed
    56. Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet. 2011 Jun; 7(6):e1002112. PMID: 21655091.
      View in: PubMed
    57. Lange S, Gögel S, Leung KY, Vernay B, Nicholas AP, Causey CP, Thompson PR, Greene ND, Ferretti P. Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biol. 2011 Jul 15; 355(2):205-14. PMID: 21539830.
      View in: PubMed
    58. Slack JL, Jones LE, Bhatia MM, Thompson PR. Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity. Biochemistry. 2011 May 17; 50(19):3997-4010. PMID: 21466234.
      View in: PubMed
    59. Rust HL, Zurita-Lopez CI, Clarke S, Thompson PR. Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry. 2011 Apr 26; 50(16):3332-45. PMID: 21417440.
      View in: PubMed
    60. Bicker KL, Sun J, Lavigne JJ, Thompson PR. Boronic acid functionalized peptidyl synthetic lectins: combinatorial library design, peptide sequencing, and selective glycoprotein recognition. ACS Comb Sci. 2011 May 9; 13(3):232-43. PMID: 21405093.
      View in: PubMed
    61. Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G929-38. PMID: 21415415.
      View in: PubMed
    62. Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol. 2011 Apr 1; 186(7):4396-404. PMID: 21346230.
      View in: PubMed
    63. Slack JL, Causey CP, Luo Y, Thompson PR. Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol. 2011 May 20; 6(5):466-76. PMID: 21265574.
      View in: PubMed
    64. Jones JE, Dreyton CJ, Flick H, Causey CP, Thompson PR. Mechanistic studies of agmatine deiminase from multiple bacterial species. Biochemistry. 2010 Nov 2; 49(43):9413-23. PMID: 20939536.
      View in: PubMed
    65. Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14; 46(38):7175-7. PMID: 20740228.
      View in: PubMed
    66. Slack JL, Causey CP, Thompson PR. Protein arginine deiminase 4: a target for an epigenetic cancer therapy. Cell Mol Life Sci. 2011 Feb; 68(4):709-20. PMID: 20706768.
      View in: PubMed
    67. Bicker KL, Obianyo O, Rust HL, Thompson PR. A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Mol Biosyst. 2011 Jan; 7(1):48-51. PMID: 20607165.
      View in: PubMed
    68. Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR. Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry. 2010 Jun 15; 49(23):4852-63. PMID: 20469888.
      View in: PubMed
    69. Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup MR, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23. PMID: 20480486.
      View in: PubMed
    70. Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR. Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem. 2010 Jan 25; 11(2):161-5. PMID: 20014086.
      View in: PubMed
    71. Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR. Characterization and inactivation of an agmatine deiminase from Helicobacter pylori. Bioorg Chem. 2010 Apr; 38(2):62-73. PMID: 20036411.
      View in: PubMed
    72. Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel. 2009 Sep; 12(5):616-27. PMID: 19736621.
      View in: PubMed
    73. Obianyo O, Osborne TC, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 1. Biochemistry. 2008 Sep 30; 47(39):10420-7. PMID: 18771293.
      View in: PubMed
    74. Causey CP, Thompson PR. An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4). Tetrahedron Lett. 2008 Jul 7; 49(28):4383-4385. PMID: 19587776.
      View in: PubMed
    75. Osborne T, Roska RL, Rajski SR, Thompson PR. In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1. J Am Chem Soc. 2008 Apr 9; 130(14):4574-5. PMID: 18338885.
      View in: PubMed
    76. Zou Y, Broughton DL, Bicker KL, Thompson PR, Lavigne JJ. Peptide borono lectins (PBLs): a new tool for glycomics and cancer diagnostics. Chembiochem. 2007 Nov 23; 8(17):2048-51. PMID: 17924602.
      View in: PubMed
    77. Osborne TC, Obianyo O, Zhang X, Cheng X, Thompson PR. Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry. 2007 Nov 20; 46(46):13370-81. PMID: 17960915.
      View in: PubMed
    78. Knuckley B, Luo Y, Thompson PR. Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem. 2008 Jan 15; 16(2):739-45. PMID: 17964793.
      View in: PubMed
    79. Knuckley B, Bhatia M, Thompson PR. Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry. 2007 Jun 5; 46(22):6578-87. PMID: 17497940.
      View in: PubMed
    80. Luo Y, Knuckley B, Bhatia M, Pellechia PJ, Thompson PR. Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. J Am Chem Soc. 2006 Nov 15; 128(45):14468-9. PMID: 17090024.
      View in: PubMed
    81. Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 3; 45(39):11727-36. PMID: 17002273.
      View in: PubMed
    82. Thompson PR, Fast W. Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock? ACS Chem Biol. 2006 Aug 22; 1(7):433-41. PMID: 17168521.
      View in: PubMed
    83. Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc. 2006 Feb 1; 128(4):1092-3. PMID: 16433522.
      View in: PubMed
    84. Kearney PL, Bhatia M, Jones NG, Yuan L, Glascock MC, Catchings KL, Yamada M, Thompson PR. Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry. 2005 Aug 9; 44(31):10570-82. PMID: 16060666.
      View in: PubMed
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