The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.

Descriptor ID	D039001
MeSH Number(s)	D12.776.543.750.705.408.100
Concept/Terms	Integrin alpha Chains Integrin alpha Chains alpha Chains, Integrin Integrin alpha Subunits alpha Integrins Integrins, alpha

Below are MeSH descriptors whose meaning is more general than "Integrin alpha Chains".

Below are MeSH descriptors whose meaning is related to "Integrin alpha Chains".

Below are MeSH descriptors whose meaning is more specific than "Integrin alpha Chains".