"Integrin alpha6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
| Descriptor ID |
D039503
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.550
|
| Concept/Terms |
Integrin alpha6- Integrin alpha6
- alpha6, Integrin
- CD49f Antigens
- alpha6 Integrin
- Integrin, alpha6
- Antigens, CD49f
- CD49f Antigen
- Antigen, CD49f
- alpha(6) Integrin
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6".
This graph shows the total number of publications written about "Integrin alpha6" by people in this website by year, and whether "Integrin alpha6" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha6" by people in Profiles.
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Mukhopadhyay D, Goel HL, Xiong C, Goel S, Kumar A, Li R, Zhu LJ, Clark JL, Brehm MA, Mercurio AM. The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin a6 mRNA splicing. Cell Rep. 2023 11 28; 42(11):113347.
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Swaminathan A, Hwang Y, Winward A, Socolovsky M. Identification and Isolation of Burst-Forming Unit and Colony-Forming Unit Erythroid Progenitors from Mouse Tissue by Flow Cytometry. J Vis Exp. 2022 11 04; (189).
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Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 07 31; 132(15).
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Schwartz AD, Hall CL, Barney LE, Babbitt CC, Peyton SR. Integrin a6 and EGFR signaling converge at mechanosensitive calpain 2. Biomaterials. 2018 09; 178:73-82.
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Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 08; 7(3):747-61.
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Wang L, Pawlak EA, Johnson PJ, Belknap JK, Eades S, Stack S, Cousin H, Black SJ. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One. 2013; 8(2):e56025.
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Tani TT, Mercurio AM. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J Biol Chem. 2001 Sep 28; 276(39):36535-42.
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Wei J, Shaw LM, Mercurio AM. Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit. J Biol Chem. 1998 Mar 06; 273(10):5903-7.
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Lotz MM, Nusrat A, Madara JL, Ezzell R, Wewer UM, Mercurio AM. Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium. Am J Pathol. 1997 Feb; 150(2):747-60.
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Becker PS, Li Z, Potselueva T, Madri JA, Newburger PE, Berliner N. Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. Blood. 1996 Jul 01; 88(1):261-7.