HIV Envelope Protein gp120

"HIV Envelope Protein gp120" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.

Descriptor ID	D015699
MeSH Number(s)	D12.776.964.775.325.164.249 D12.776.964.775.562.500.500 D12.776.964.970.880.325.164.249 D23.050.327.520.350
Concept/Terms	HIV Envelope Protein gp120 HIV Envelope Protein gp120 Envelope Glycoprotein gp120, HIV gp120 Envelope Glycoprotein, HIV HIV Envelope Glycoprotein gp120 HTLV-III gp120 HTLV III gp120 gp120, HTLV-III env Protein gp120, HIV gp120(HIV)

Below are MeSH descriptors whose meaning is more general than "HIV Envelope Protein gp120".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, env [D12.776.964.775.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.325.164]
HIV Envelope Protein gp120 [D12.776.964.775.325.164.249]
Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.500]
HIV Envelope Protein gp120 [D12.776.964.775.562.500.500]
Viral Structural Proteins [D12.776.964.970]
Viral Envelope Proteins [D12.776.964.970.880]
Gene Products, env [D12.776.964.970.880.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.970.880.325.164]
HIV Envelope Protein gp120 [D12.776.964.970.880.325.164.249]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Viral [D23.050.327]
HIV Antigens [D23.050.327.520]
HIV Envelope Protein gp120 [D23.050.327.520.350]

Below are MeSH descriptors whose meaning is related to "HIV Envelope Protein gp120".

Below are MeSH descriptors whose meaning is more specific than "HIV Envelope Protein gp120".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HIV Envelope Protein gp120" by people in this website by year, and whether "HIV Envelope Protein gp120" was a major or minor topic of these publications.

Bar chart showing 85 publications over 27 distinct years, with a maximum of 7 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	2	5
1996	1	2	3
1998	1	1	2
1999	1	0	1
2000	1	1	2
2001	0	1	1
2002	1	2	3
2003	3	2	5
2004	1	2	3
2005	2	2	4
2006	3	2	5
2007	3	0	3
2008	5	2	7
2009	3	0	3
2010	6	0	6
2011	0	2	2
2012	5	1	6
2013	2	0	2
2014	3	1	4
2015	1	1	2
2016	2	1	3
2017	3	0	3
2018	2	3	5
2019	1	0	1
2020	2	0	2
2021	1	0	1
2024	0	1	1

Below are the most recent publications written about "HIV Envelope Protein gp120" by people in Profiles.

Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, McKee K, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S. Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun. 2024 May 21; 15(1):4301.

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Li H, Wang S, Hu G, Zhang L, Liu S, Lu S. DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses. Emerg Microbes Infect. 2021 Dec; 10(1):833-841.

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Wang S, Voronin Y, Zhao P, Ishihara M, Mehta N, Porterfield M, Chen Y, Bartley C, Hu G, Han D, Wells L, Tiemeyer M, Lu S. Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions. J Virol. 2020 03 17; 94(7).

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Soare AY, Malik HS, Durham ND, Freeman TL, Alvarez R, Patel F, Satija N, Upadhyay C, Hioe CE, Chen BK, Swartz TH. P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion. J Virol. 2020 02 28; 94(6).

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Lamers SL, Fogel GB, Nolan DJ, Barbier AE, Rose R, Singer EJ, Gonzalez-Perez MP, McGrath MS. Emerging Patterns in HIV-1 gp120 Variable Domains in Anatomical Tissues in the Absence of a Plasma Viral Load. AIDS Res Hum Retroviruses. 2019 06; 35(6):588-596.

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Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2019 02 01; 202(3):799-804.

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Quitadamo B, Peters PJ, Koch M, Luzuriaga K, Cheng-Mayer C, Clapham PR, Gonzalez-Perez MP. No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications. Arch Virol. 2019 Feb; 164(2):473-482.

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Munro JB. HIV Env on Lockdown. Cell Host Microbe. 2018 06 13; 23(6):699-701.

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Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G. Exploiting glycan topography for computational design of Env glycoprotein antigenicity. PLoS Comput Biol. 2018 04; 14(4):e1006093.

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Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018 03 21; 7.

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