Vaccines, DNA

"Vaccines, DNA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

Descriptor ID	D019444
MeSH Number(s)	D12.776.828.868.910 D20.215.894.865.910 D23.050.865.910
Concept/Terms	Vaccines, DNA Vaccines, DNA Recombinant DNA Vaccines DNA Vaccines, Recombinant DNA Vaccines Naked DNA Vaccines DNA Vaccines, Naked Vaccines, Naked DNA Vaccines, Recombinant DNA Polynucleotide Vaccines Polynucleotide Vaccines Vaccines, Polynucleotide Nucleic Acid Vaccines Nucleic Acid Vaccines Vaccines, Nucleic Acid

Below are MeSH descriptors whose meaning is more general than "Vaccines, DNA".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Recombinant Proteins [D12.776.828]
Vaccines, Synthetic [D12.776.828.868]
Vaccines, DNA [D12.776.828.868.910]
Complex Mixtures [D20]
Biological Products [D20.215]
Vaccines [D20.215.894]
Vaccines, Synthetic [D20.215.894.865]
Vaccines, DNA [D20.215.894.865.910]
Biological Factors [D23]
Antigens [D23.050]
Vaccines, Synthetic [D23.050.865]
Vaccines, DNA [D23.050.865.910]

Below are MeSH descriptors whose meaning is related to "Vaccines, DNA".

Below are MeSH descriptors whose meaning is more specific than "Vaccines, DNA".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Vaccines, DNA" by people in this website by year, and whether "Vaccines, DNA" was a major or minor topic of these publications.

Bar chart showing 82 publications over 22 distinct years, with a maximum of 10 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	5	1	6
1999	3	3	6
2000	3	2	5
2001	0	2	2
2003	0	1	1
2004	0	2	2
2005	1	2	3
2006	3	1	4
2007	1	3	4
2008	8	2	10
2009	2	5	7
2010	3	3	6
2011	3	1	4
2013	5	0	5
2014	2	3	5
2015	1	1	2
2016	1	2	3
2017	2	0	2
2018	1	0	1
2019	0	1	1
2021	1	0	1
2024	0	2	2

Below are the most recent publications written about "Vaccines, DNA" by people in Profiles.

Escalante GM, Reidel IG, Mutsvunguma LZ, Cua S, Tello BA, Rodriguez E, Farelo MA, Zimmerman C, Muniraju M, Li H, Govindan AN, Axthelm MK, Wong SW, Ogembo JG. Multivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice. Front Immunol. 2024; 15:1445209.

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Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, McKee K, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S. Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun. 2024 May 21; 15(1):4301.

View in: PubMed
Li H, Wang S, Hu G, Zhang L, Liu S, Lu S. DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses. Emerg Microbes Infect. 2021 Dec; 10(1):833-841.

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Pontes Ferreira C, Cariste LM, Ferri Moraschi B, Ferrarini Zanetti B, Won Han S, Araki Ribeiro D, Vieira Machado A, Lannes-Vieira J, Gazzinelli RT, Vasconcelos JRC. CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge. PLoS Negl Trop Dis. 2019 07; 13(7):e0007597.

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Flotte TR, Lu S. DNA Vaccination in 2018: An Update. Hum Gene Ther. 2018 09; 29(9):963-965.

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Wang S, Chou TH, Hackett A, Efros V, Wang Y, Han D, Wallace A, Chen Y, Hu G, Liu S, Clapham P, Arthos J, Montefiori D, Lu S. Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines. Hum Vaccin Immunother. 2017 12 02; 13(12):2996-3009.

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Keele BF, Li W, Borducchi EN, Nkolola JP, Abbink P, Chen B, Seaman MS, Barouch DH. Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys. Nat Commun. 2017 06 05; 8:15740.

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Costa MR, Pollara J, Edwards RW, Seaman MS, Gorny MK, Montefiori DC, Liao HX, Ferrari G, Lu S, Wang S. Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001. J Virol. 2016 Nov 15; 90(22):10362-10378.

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Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science. 2016 09 09; 353(6304):1129-32.

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Larocca RA, Abbink P, Peron JP, Zanotto PM, Iampietro MJ, Badamchi-Zadeh A, Boyd M, Ng'ang'a D, Kirilova M, Nityanandam R, Mercado NB, Li Z, Moseley ET, Bricault CA, Borducchi EN, Giglio PB, Jetton D, Neubauer G, Nkolola JP, Maxfield LF, De La Barrera RA, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Vaccine protection against Zika virus from Brazil. Nature. 2016 08 25; 536(7617):474-8.

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