Plague

"Plague" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.

Descriptor ID	D010930
MeSH Number(s)	C01.252.400.310.980.745
Concept/Terms	Plague Plague Yersinia pestis Infection Infection, Yersinia pestis Infections, Yersinia pestis Yersinia pestis Infections Septicemic Plague Septicemic Plague Plague, Septicemic Plagues, Septicemic Septicemic Plagues Black Death Black Deaths Death, Black Deaths, Black Black Plague Black Plagues Plague, Black Plagues, Black Pneumonic Plague Pneumonic Plague Plague, Pneumonic Plagues, Pneumonic Pneumonic Plagues Pulmonic Plague Pulmonic Plague Plague, Pulmonic Plagues, Pulmonic Pulmonic Plagues Bubonic Plague Bubonic Plague Plague, Bubonic Meningeal Plague Meningeal Plague Meningeal Plagues Plague, Meningeal Plagues, Meningeal

Below are MeSH descriptors whose meaning is more general than "Plague".

Diseases [C]
Bacterial Infections and Mycoses [C01]
Bacterial Infections [C01.252]
Gram-Negative Bacterial Infections [C01.252.400]
Enterobacteriaceae Infections [C01.252.400.310]
Yersinia Infections [C01.252.400.310.980]
Plague [C01.252.400.310.980.745]

Below are MeSH descriptors whose meaning is related to "Plague".

Below are MeSH descriptors whose meaning is more specific than "Plague".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Plague" by people in this website by year, and whether "Plague" was a major or minor topic of these publications.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 2 publications in 2004 and 2008 and 2009 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	2	0	2
2006	1	0	1
2007	1	0	1
2008	2	0	2
2009	2	0	2
2010	1	0	1
2011	1	0	1
2012	1	1	2
2016	1	0	1
2018	1	0	1
2020	1	0	1

Below are the most recent publications written about "Plague" by people in Profiles.

Palace SG, Vitseva O, Proulx MK, Freedman JE, Goguen JD, Koupenova M. Yersinia pestis escapes entrapment in thrombi by targeting platelet function. J Thromb Haemost. 2020 12; 18(12):3236-3248.

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Pulsifer AR, Vashishta A, Reeves SA, Wolfe JK, Palace SG, Proulx MK, Goguen J, Bodduluri SR, Haribabu B, Uriarte SM, Lawrenz MB. Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach. Infect Immun. 2020 02 20; 88(3).

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Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 11 30; 362(6418):1064-1069.

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Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathog. 2016 Dec; 12(12):e1006035.

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Anderson PD, Bokor G. Bioterrorism: pathogens as weapons. J Pharm Pract. 2012 Oct; 25(5):521-9.

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Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012 Jul 27; 37(1):96-107.

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Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGF?-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12710-5.

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Wang S, Goguen JD, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011 Sep 09; 29(39):6802-9.

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Wang S, Mboudjeka I, Goguen JD, Lu S. Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines. Vaccine. 2010 Feb 23; 28(8):2011-9.

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Szaba FM, Kummer LW, Wilhelm LB, Lin JS, Parent MA, Montminy-Paquette SW, Lien E, Johnson LL, Smiley ST. D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague. Infect Immun. 2009 Oct; 77(10):4295-304.

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