"Genes, APC" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Descriptor ID |
D017491
|
MeSH Number(s) |
G05.360.340.024.340.375.249.050 G05.360.340.024.340.415.400.050
|
Concept/Terms |
Genes, APC- Genes, APC
- APC Gene
- APC Genes
- Gene, APC
- Genes, Adenomatous Polyposis Coli
|
Below are MeSH descriptors whose meaning is more general than "Genes, APC".
Below are MeSH descriptors whose meaning is more specific than "Genes, APC".
This graph shows the total number of publications written about "Genes, APC" by people in this website by year, and whether "Genes, APC" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2002 | 3 | 0 | 3 |
2007 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Genes, APC" by people in Profiles.
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Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE. Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 2010 Aug; 19(8):1153-66.
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Davids JS, Carothers AM, Damas BC, Bertagnolli MM. Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis. Cancer Prev Res (Phila). 2010 Mar; 3(3):348-58.
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Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Plough HL, Barrett TA, Weissleder R, Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One. 2008 Aug 13; 3(8):e2916.
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Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med. 2007 Nov; 13(11):1286-7.
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Hughes SA, Carothers AM, Hunt DH, Moran AE, Mueller JD, Bertagnolli MM. Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis. J Gastrointest Surg. 2002 Nov-Dec; 6(6):868-74; discussion 875.
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Heinen CD, Goss KH, Cornelius JR, Babcock GF, Knudsen ES, Kowalik T, Groden J. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology. 2002 Sep; 123(3):751-63.
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Lew JI, Guo Y, Kim RK, Vargish L, Michelassi F, Arenas RB. Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. J Gastrointest Surg. 2002 Jul-Aug; 6(4):563-8.