Genes, Tumor Suppressor

"Genes, Tumor Suppressor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Descriptor ID	D016147
MeSH Number(s)	G05.360.340.024.340.375.249 G05.360.340.024.340.415.400
Concept/Terms	Genes, Tumor Suppressor Genes, Tumor Suppressor Gene, Tumor Suppressor Tumor Suppressor Gene Antioncogenes Antioncogene Emerogenes Emerogene Genes, Onco-Suppressor Gene, Onco-Suppressor Genes, Onco Suppressor Onco-Suppressor Gene Onco-Suppressor Genes Cancer Suppressor Genes Cancer Suppressor Gene Gene, Cancer Suppressor Suppressor Gene, Cancer Suppressor Genes, Cancer Oncogenes, Recessive Oncogene, Recessive Recessive Oncogene Recessive Oncogenes Anti-Oncogenes Anti Oncogenes Anti-Oncogene Tumor Suppressing Genes Gene, Tumor Suppressing Genes, Tumor Suppressing Tumor Suppressing Gene Genes, Cancer Suppressor Tumor Suppressor Genes Metastasis Suppressor Genes Metastasis Suppressor Genes Gene, Metastasis Suppressor Metastasis Suppressor Gene Suppressor Gene, Metastasis Suppressor Genes, Metastasis Genes, Metastasis Suppressor Growth Suppressor Genes Growth Suppressor Genes Gene, Growth Suppressor Growth Suppressor Gene Suppressor Gene, Growth Suppressor Genes, Growth Genes, Growth Suppressor

Below are MeSH descriptors whose meaning is more general than "Genes, Tumor Suppressor".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Genes, Tumor Suppressor [G05.360.340.024.340.375.249]
Genes, Recessive [G05.360.340.024.340.415]
Genes, Tumor Suppressor [G05.360.340.024.340.415.400]

Below are MeSH descriptors whose meaning is related to "Genes, Tumor Suppressor".

Below are MeSH descriptors whose meaning is more specific than "Genes, Tumor Suppressor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, Tumor Suppressor" by people in this website by year, and whether "Genes, Tumor Suppressor" was a major or minor topic of these publications.

Bar chart showing 64 publications over 22 distinct years, with a maximum of 5 publications in 2001 and 2004 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	1	0	1
2000	2	1	3
2001	3	2	5
2002	1	3	4
2003	3	1	4
2004	1	4	5
2005	0	3	3
2007	3	1	4
2008	2	2	4
2009	1	1	2
2010	1	3	4
2011	2	1	3
2012	5	0	5
2013	2	1	3
2014	1	2	3
2015	1	2	3
2016	1	1	2
2018	0	2	2
2019	0	1	1
2021	0	1	1
2024	0	1	1

Below are the most recent publications written about "Genes, Tumor Suppressor" by people in Profiles.

Cirrincione AM, Poos AM, Ziccheddu B, Kaddoura M, B?rtsch MA, Maclachlan K, Chojnacka M, Diamond B, John L, Reichert P, Huhn S, Blaney P, Gagler D, Rippe K, Zhang Y, Dogan A, Lesokhin AM, Davies F, Goldschmidt H, Fenk R, Weisel KC, Mai EK, Korde N, Morgan GJ, Usmani S, Landgren O, Raab MS, Weinhold N, Maura F. The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma. Blood. 2024 08 15; 144(7):771-783.

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Yakirevich E, Pavlick DC, Perrino CM, Stanton M, Lu S, Carneiro B, Bratslavsky G, Ross JS. NF2 Tumor Suppressor Gene Inactivation in Advanced Papillary Renal Cell Carcinoma. Am J Surg Pathol. 2021 05 01; 45(5):716-718.

View in: PubMed
Paul D, Islam S, Manne RK, Dinesh US, Malonia SK, Maity B, Boppana R, Rapole S, Shetty PK, Santra MK. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear ?-catenin function. J Pathol. 2019 07; 248(3):266-279.

View in: PubMed
Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019 01 24; 176(3):564-580.e19.

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Liu Q, Cornejo KM, Cheng L, Hutchinson L, Wang M, Zhang S, Tomaszewicz K, Cosar EF, Woda BA, Jiang Z. Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. Am J Pathol. 2018 04; 188(4):846-852.

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Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne PH, Kim ES, Shohet JM. Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Oncotarget. 2016 Apr 26; 7(17):24018-26.

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Hallstrom KN, McCormick BA. The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection. Gut Microbes. 2016; 7(2):136-45.

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Zhuang J, Weng Z. Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes. Nucleic Acids Res. 2015 Sep 30; 43(17):8146-56.

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Fang M, Pak ML, Chamberlain L, Xing W, Yu H, Green MR. The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes. Cell Rep. 2015 Jun 09; 11(9):1350-7.

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Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA. PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. 2015 Jun; 17(6):843-59.

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