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Read Pukkila-Worley MD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street
Worcester MA 01605
Phone508-856-3596
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    Indiana University Bloomington, Bloomington, IN, United StatesBSBiology
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesMD

    Collapse Overview 
    Collapse overview


    For information about our work, please visit the Pukkila-Worley lab website (http://www.umassmed.edu/pukkila-worleylab).




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP. Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proc Natl Acad Sci U S A. 2019 Oct 14. PMID: 31611372.
      View in: PubMed
    2. Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R. The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans. PLoS Pathog. 2019 Jun 17; 15(6):e1007893. PMID: 31206555.
      View in: PubMed
    3. Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM. Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3. Proc Natl Acad Sci U S A. 2019 Mar 08. PMID: 30850535.
      View in: PubMed
    4. Peterson ND, Cheesman HK, Liu P, Anderson SM, Foster KJ, Chhaya R, Perrat P, Thekkiniath J, Yang Q, Haynes CM, Pukkila-Worley R. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans. PLoS Genet. 2019 Jan 22; 15(1):e1007935. PMID: 30668573.
      View in: PubMed
    5. Ding W, Higgins DP, Yadav DK, Godbole AA, Pukkila-Worley R, Walker AK. Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine. PLoS Genet. 2018 Nov 28; 14(11):e1007812. PMID: 30485261.
      View in: PubMed
    6. Peterson ND, Pukkila-Worley R. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Curr Opin Immunol. 2018 Jun 20; 54:59-65. PMID: 29935375.
      View in: PubMed
    7. Pukkila-Worley R. Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans. PLoS Pathog. 2016 Sep; 12(9):e1005795. PMID: 27631629.
      View in: PubMed
    8. Cheesman HK, Feinbaum RL, Thekkiniath J, Dowen RH, Conery AL, Pukkila-Worley R. Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans. G3 (Bethesda). 2016 Jan 27; 6(3):541-9. PMID: 26818074.
      View in: PubMed
    9. Pukkila-Worley R. Case 28-2014: A man with a rash, headache, fever, nausea, and photophobia. N Engl J Med. 2014 Dec 4; 371(23):2239. PMID: 25470710.
      View in: PubMed
    10. Pukkila-Worley R, Nardi V, Branda JA. Case records of the Massachusetts General Hospital. Case 28-2014. A 39-year-old man with a rash, headache, fever, nausea, and photophobia. N Engl J Med. 2014 Sep 11; 371(11):1051-60. PMID: 25207769.
      View in: PubMed
    11. Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLoS Pathog. 2014 May; 10(5):e1004143. PMID: 24875643.
      View in: PubMed
    12. Tan X, Fuchs BB, Wang Y, Chen W, Yuen GJ, Chen RB, Jayamani E, Anastassopoulou C, Pukkila-Worley R, Coleman JJ, Mylonakis E. The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis. PLoS One. 2014; 9(4):e94468. PMID: 24732310.
      View in: PubMed
    13. Chan BT, Hohmann E, Barshak MB, Pukkila-Worley R. Treatment of listeriosis in first trimester of pregnancy. Emerg Infect Dis. 2013 May; 19(5):839-41. PMID: 23697599.
      View in: PubMed
    14. Uppuluri P, Chaturvedi AK, Jani N, Pukkila-Worley R, Monteagudo C, Mylonakis E, Köhler JR, Lopez Ribot JL. Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis. Eukaryot Cell. 2012 Dec; 11(12):1552-6. PMID: 23104566.
      View in: PubMed
    15. Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012; 8(6):e1002733. PMID: 22719261.
      View in: PubMed
    16. Pukkila-Worley R, Ausubel FM. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol. 2012 Feb; 24(1):3-9. PMID: 22236697.
      View in: PubMed
    17. Pukkila-Worley R, Ausubel FM, Mylonakis E. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog. 2011 Jun; 7(6):e1002074. PMID: 21731485.
      View in: PubMed
    18. Pukkila-Worley R, Mylonakis E. From the outside in and the inside out: Antifungal immune responses in Caenorhabditis elegans. Virulence. 2010 May-Jun; 1(3):111-2. PMID: 21178428.
      View in: PubMed
    19. Pukkila-Worley R, Peleg AY, Tampakakis E, Mylonakis E. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryot Cell. 2009 Nov; 8(11):1750-8. PMID: 19666778.
      View in: PubMed
    20. Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009 Mar 16; 206(3):637-53. PMID: 19237602.
      View in: PubMed
    21. Pukkila-Worley R, Mylonakis E. Epidemiology and management of cryptococcal meningitis: developments and challenges. Expert Opin Pharmacother. 2008 Mar; 9(4):551-60. PMID: 18312157.
      View in: PubMed
    22. Fraser JA, Huang JC, Pukkila-Worley R, Alspaugh JA, Mitchell TG, Heitman J. Chromosomal translocation and segmental duplication in Cryptococcus neoformans. Eukaryot Cell. 2005 Feb; 4(2):401-6. PMID: 15701802.
      View in: PubMed
    23. Pukkila-Worley R, Gerrald QD, Kraus PR, Boily MJ, Davis MJ, Giles SS, Cox GM, Heitman J, Alspaugh JA. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryot Cell. 2005 Jan; 4(1):190-201. PMID: 15643074.
      View in: PubMed
    24. Pukkila-Worley R, Alspaugh JA. Cyclic AMP signaling in Cryptococcus neoformans. FEMS Yeast Res. 2004 Jan; 4(4-5):361-7. PMID: 14734016.
      View in: PubMed
    25. Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell. 2002 Feb; 1(1):75-84. PMID: 12455973.
      View in: PubMed
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