"Simvastatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
| Descriptor ID |
D019821
|
| MeSH Number(s) |
D02.455.426.559.847.638.400.900 D04.615.638.400.900
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Simvastatin".
Below are MeSH descriptors whose meaning is more specific than "Simvastatin".
This graph shows the total number of publications written about "Simvastatin" by people in this website by year, and whether "Simvastatin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 2 | 2 | 4 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Simvastatin" by people in Profiles.
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Degrush E, Shazeeb MS, Drachman D, Vardar Z, Lindsay C, Gounis MJ, Henninger N. Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease. Alzheimers Res Ther. 2022 Sep 17; 14(1):134.
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Vanderweil SG, Amano S, Ko WC, Richmond JM, Kelley M, Senna MM, Pearson A, Chowdary S, Hartigan C, Barton B, Harris JE. A double-blind, placebo-controlled, phase-II clinical trial to evaluate oral simvastatin as a treatment for vitiligo. J Am Acad Dermatol. 2017 Jan; 76(1):150-151.e3.
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Deren ME, Ehteshami JR, Dines JS, Drakos MC, Behrens SB, Doty S, Coleman SH. Simvastatin Exposure and Rotator Cuff Repair in a Rat Model. Orthopedics. 2017 Mar 01; 40(2):e288-e292.
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Schierwagen R, Mayb?chen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, L?tjohann D, Zimmer S, Trebicka J. Statins improve NASH via inhibition of RhoA and Ras. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G724-G733.
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Wang A, Stefanick ML, Kapphahn K, Hedlin H, Desai M, Manson JA, Strickler H, Martin L, Wactawski-Wende J, Simon M, Tang JY. Relation of statin use with non-melanoma skin cancer: prospective results from the Women's Health Initiative. Br J Cancer. 2016 Feb 02; 114(3):314-20.
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Jarcho JA, Keaney JF. Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT. N Engl J Med. 2015 Jun 18; 372(25):2448-50.
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Agarwal P, Rashighi M, Essien KI, Richmond JM, Randall L, Pazoki-Toroudi H, Hunter CA, Harris JE. Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo. J Invest Dermatol. 2015 Apr; 135(4):1080-1088.
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Bajaj R, Chhabra L, Kruger M, Kumar D. Mobile complex atherosclerotic aortic plaque. BMJ Case Rep. 2013 Apr 20; 2013.
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Johnson MA, Cadavid D. Simvastatin in acute optic neuritis. Mult Scler. 2012 Nov; 18(11):1657; author reply 1658.
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Carey KM, Comee MR, Donovan JL, Kanaan AO. A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke. Ann Pharmacother. 2012 May; 46(5):688-95.