Immunoglobulin Fab Fragments

"Immunoglobulin Fab Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Descriptor ID	D007140
MeSH Number(s)	D12.644.541.500.650 D12.776.124.486.485.680.650 D12.776.124.790.651.680.650 D12.776.377.715.548.680.650
Concept/Terms	Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments Fab Fragments, Immunoglobulin Immunoglobulins, Fab Fragment Fab Fragment Immunoglobulins Fragment Immunoglobulins, Fab Immunoglobulin Fab Fragment Fab Fragment, Immunoglobulin Fab Immunoglobulin Fragments Immunoglobulin Fragments, Fab Fab Fragments Immunoglobulins, Fab

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fab Fragments".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Fab Fragments".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fab Fragments".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Fab Fragments" by people in this website by year, and whether "Immunoglobulin Fab Fragments" was a major or minor topic of these publications.

Bar chart showing 31 publications over 18 distinct years, with a maximum of 5 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
2000	0	1	1
2001	1	0	1
2002	2	3	5
2003	2	1	3
2004	1	1	2
2005	2	1	3
2006	0	1	1
2007	1	1	2
2009	0	1	1
2011	0	1	1
2013	1	0	1
2015	0	1	1
2017	1	1	2
2021	0	1	1
2022	0	2	2
2023	0	1	1
2024	0	2	2

Below are the most recent publications written about "Immunoglobulin Fab Fragments" by people in Profiles.

Rudolph MJ, Chen Y, Vorauer C, Vance DJ, Piazza CL, Willsey GG, McCarthy K, Muriuki B, Cavacini LA, Guttman M, Mantis NJ. Structure of a Human Monoclonal Antibody in Complex with Outer Surface Protein C of the Lyme Disease Spirochete, Borreliella burgdorferi. J Immunol. 2024 Oct 15; 213(8):1234-1243.

View in: PubMed
Danzig CJ, Khanani AM, Kaiser PK, Chang MA, Kovach JL, Lally DR, Rachitskaya A, Sheth VS, Vajzovic L, Clark J, Tang J, Zhu L, Desai D, Chakravarthy U. Vision Loss Reduction with Avacincaptad Pegol for Geographic Atrophy: A 12-Month Post Hoc Analysis of the GATHER1 and GATHER2 Trials. Ophthalmol Retina. 2024 Nov; 8(11):1052-1060.

View in: PubMed
Rudolph MJ, Davis SA, Haque HME, Ejemel M, Cavacini LA, Vance DJ, Willsey GG, Piazza CL, Weis DD, Wang Y, Mantis NJ. Structure of a transmission blocking antibody in complex with Outer surface protein A from the Lyme disease spirochete, Borreliella burgdorferi. Proteins. 2023 Nov; 91(11):1463-1470.

View in: PubMed
Frye AM, Ejemel M, Cavacini L, Wang Y, Rudolph MJ, Song R, Mantis NJ. Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments. Infect Immun. 2022 09 15; 90(9):e0030622.

View in: PubMed
Singh K, Canakci M, Kanjilal P, Williams N, Shanthalingam S, Osborne BA, Thayumanavan S. Evaluation of Cellular Targeting by Fab' vs Full-Length Antibodies in Antibody-Nanoparticle Conjugates (ANCs) Using CD4 T-cells. Bioconjug Chem. 2022 03 16; 33(3):486-495.

View in: PubMed
B?uerle T, Gupta S, Zheng S, Seyler L, Leporati A, Marosfoi M, Maschauer S, Prante O, Caravan P, Bogdanov A. Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model. Radiol Imaging Cancer. 2021 07; 3(4):e200069.

View in: PubMed
Harrold LR, Litman HJ, Connolly SE, Kelly S, Hua W, Alemao E, Rosenblatt L, Rebello S, Kremer JM. Effect of Anticitrullinated Protein Antibody Status on Response to Abatacept or Antitumor Necrosis Factor-a Therapy in Patients with Rheumatoid Arthritis: A US National Observational Study. J Rheumatol. 2018 01; 45(1):32-39.

View in: PubMed
Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839.

View in: PubMed
Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, F?ndrich M, Grigorieff N. Peptide dimer structure in an A?(1-42) fibril visualized with cryo-EM. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11858-63.

View in: PubMed
Beernink PT, Giuntini S, Costa I, Lucas AH, Granoff DM. Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein. mBio. 2015 Jun 23; 6(3):e00842.

View in: PubMed

People

Explore

Similar Concepts

Top Journals