Immunoglobulin Variable Region

"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Descriptor ID	D007135
MeSH Number(s)	D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
Concept/Terms	Immunoglobulin Variable Region Immunoglobulin Variable Region Immunoglobulin Variable Regions Regions, Immunoglobulin Variable Variable Regions, Immunoglobulin Ig Variable Region Variable Region, Ig Ig Variable Regions Variable Regions, Ig Variable Region, Immunoglobulin Immunoglobulin V Immunoglobulin Fv Fragments Immunoglobulin Fv Fragments Fragment, Immunoglobulin Fv Fragments, Immunoglobulin Fv Fv Fragment, Immunoglobulin Fv Fragments, Immunoglobulin Immunoglobulin Fv Fragment Fv Antibody Fragments Antibody Fragment, Fv Antibody Fragments, Fv Fragment, Fv Antibody Fragments, Fv Antibody Fv Antibody Fragment Fv Fragments Fragment, Fv Fragments, Fv Fv Fragment Framework Region, Immunoglobulin Framework Region, Immunoglobulin Framework Regions, Immunoglobulin Immunoglobulin Framework Regions Ig Framework Region Framework Region, Ig Framework Regions, Ig Ig Framework Regions Immunoglobulin Framework Region

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Immunoglobulin Variable Region [D12.776.124.486.485.797]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Immunoglobulin Variable Region [D12.776.124.790.651.797]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Immunoglobulin Variable Region [D12.776.377.715.548.797]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Immunoglobulin Variable Region [G02.111.570.060.425]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Variable Region".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.

Bar chart showing 22 publications over 16 distinct years, with a maximum of 2 publications in 1998 and 2001 and 2003 and 2007 and 2013 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	1	1
1998	1	1	2
1999	0	1	1
2000	1	0	1
2001	1	1	2
2003	0	2	2
2004	0	1	1
2005	1	0	1
2007	1	1	2
2008	0	1	1
2009	0	1	1
2013	2	0	2
2014	0	1	1
2017	1	0	1
2021	1	1	2

Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.

Duggan NN, Weisgrau KL, Magnani DM, Rakasz EG, Desrosiers RC, Martinez-Navio JM. SOSIP Trimer-Specific Antibodies Isolated from a Simian-Human Immunodeficiency Virus-Infected Monkey with versus without a Pre-blocking Step with gp41. J Virol. 2022 01 26; 96(2):e0158221.

View in: PubMed
Borowska MT, Drees C, Yarawsky AE, Viswanathan M, Ryan SM, Bunker JJ, Herr AB, Bendelac A, Adams EJ. The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39).

View in: PubMed
Farf?n-Arribas DJ, Liu S, Wang S, Lu S. The dynamics of immunoglobulin V-gene usage and clonotype expansion in mice after prime and boost immunizations as analyzed by NGS. Hum Vaccin Immunother. 2017 12 02; 13(12):2987-2995.

View in: PubMed
Maul RW, Cao Z, Venkataraman L, Giorgetti CA, Press JL, Denizot Y, Du H, Sen R, Gearhart PJ. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells. J Exp Med. 2014 Oct 20; 211(11):2297-306.

View in: PubMed
Sacha CR, Vandergrift N, Jeffries TL, McGuire E, Fouda GG, Liebl B, Marshall DJ, Gurley TC, Stiegel L, Whitesides JF, Friedman J, Badiabo A, Foulger A, Yates NL, Tomaras GD, Kepler TB, Liao HX, Haynes BF, Moody MA, Permar SR. Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women. Mucosal Immunol. 2015 Mar; 8(2):316-26.

View in: PubMed
Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J. DNA polymerases ? and ? do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst). 2013 Dec; 12(12):1087-93.

View in: PubMed
Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475.

View in: PubMed
Butler JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J, Francis DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Mol Immunol. 2011 Dec; 49(3):483-94.

View in: PubMed
Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96.

View in: PubMed
Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008 Aug 22; 134(4):577-86.

View in: PubMed

People

Explore

Similar Concepts

Top Journals