Complementarity Determining Regions

"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).

Descriptor ID	D022801
MeSH Number(s)	D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
Concept/Terms	Complementarity Determining Regions Complementarity Determining Regions Region, Complementarity Determining Regions, Complementarity Determining Hypervariable Regions, Immunoglobulin Hypervariable Region, Immunoglobulin Immunoglobulin Hypervariable Region Immunoglobulin Hypervariable Regions Region, Immunoglobulin Hypervariable Regions, Immunoglobulin Hypervariable Complementarity Determining Region Complementarity-Determining Region Complementarity-Determining Regions Regions, Complementarity-Determining Complementarity Determining Region 3 Complementarity Determining Region 3 Complementarity-Determining Region 3 Complementarity-Determining Region 3s Third Complementarity-Determining Region Complementarity-Determining Region, Third Complementarity-Determining Regions, Third Third Complementarity Determining Region Third Complementarity-Determining Regions Complementarity Determining Region III Complementarity Determining Region 1 Complementarity Determining Region 1 Complementarity Determining Region I Complementarity Determining Region 2 Complementarity Determining Region 2 Complementarity Determining Region II

Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Complementarity Determining Regions [D12.644.541.500.650.500.180]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.486.485.797]
Complementarity Determining Regions [D12.776.124.486.485.797.180]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.790.651.797]
Complementarity Determining Regions [D12.776.124.790.651.797.180]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
Immunoglobulin Variable Region [D12.776.377.715.548.797]
Complementarity Determining Regions [D12.776.377.715.548.797.180]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Antigen [D12.776.543.750.705.816]
Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
Complementarity Determining Regions [D12.776.543.750.705.816.824.300]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Immunoglobulin Variable Region [G02.111.570.060.425]
Complementarity Determining Regions [G02.111.570.060.425.160]

Below are MeSH descriptors whose meaning is related to "Complementarity Determining Regions".

Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.

Bar chart showing 28 publications over 17 distinct years, with a maximum of 3 publications in 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2002	1	1	2
2003	0	2	2
2005	1	1	2
2006	1	1	2
2007	0	1	1
2008	2	0	2
2009	0	2	2
2011	0	1	1
2012	0	1	1
2014	2	0	2
2016	1	0	1
2017	0	1	1
2019	2	1	3
2020	0	3	3
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.

Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, McKee K, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S. Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun. 2024 May 21; 15(1):4301.

View in: PubMed
Clark F, Gil A, Thapa I, Aslan N, Ghersi D, Selin LK. Cross-reactivity influences changes in human influenza A virus and Epstein Barr virus specific CD8 memory T cell receptor alpha and beta repertoires between young and old. Front Immunol. 2022; 13:1011935.

View in: PubMed
D'Onofrio A, Gano L, Melo R, Mendes F, Oliveira MC, Deno?l T, Schaefer N, Viertl D, Fierle J, Coukos G, Dunn S, Prior JO, Paulo A. Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies. Eur J Pharm Biopharm. 2021 Jan; 158:233-244.

View in: PubMed
Aliseychik M, Patrikeev A, Gusev F, Grigorenko A, Andreeva T, Biragyn A, Rogaev E. Dissection of the Human T-Cell Receptor ? Gene Repertoire in the Brain and Peripheral Blood Identifies Age- and Alzheimer's Disease-Associated Clonotype Profiles. Front Immunol. 2020; 11:12.

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Ogongo P, Steyn AJ, Karim F, Dullabh KJ, Awala I, Madansein R, Leslie A, Behar SM. Differential skewing of donor-unrestricted and ?d T cell repertoires in tuberculosis-infected human lungs. J Clin Invest. 2020 01 02; 130(1):214-230.

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Kamga L, Gil A, Song I, Brody R, Ghersi D, Aslan N, Stern LJ, Selin LK, Luzuriaga K. CDR3a?drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection. PLoS Pathog. 2019 11; 15(11):e1008122.

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Mutsvunguma LZ, Rodriguez E, Escalante GM, Muniraju M, Williams JC, Warden C, Qin H, Wang J, Wu X, Barasa A, Mulama DH, Mwangi W, Ogembo JG. Identification of multiple potent neutralizing and non-neutralizing antibodies against Epstein-Barr virus gp350 protein with potential for clinical application and as reagents for mapping immunodominant epitopes. Virology. 2019 10; 536:1-15.

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Negroni MP, Cho OH, Stern LJ. Recognition of Listeria Infection by Germline Elements of the V?1.1 Vd6.3 TCR. Immunohorizons. 2019 07 18; 3(7):341-351.

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Song I, Gil A, Mishra R, Ghersi D, Selin LK, Stern LJ. Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope. Nat Struct Mol Biol. 2017 04; 24(4):395-406.

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Stadinski BD, Shekhar K, G?mez-Touri?o I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol. 2016 08; 17(8):946-55.

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