Single-Chain Antibodies

"Single-Chain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

Descriptor ID	D057127
MeSH Number(s)	D12.644.541.500.650.500.800 D12.776.124.486.485.114.224.785 D12.776.124.486.485.680.650.500.800 D12.776.124.790.651.680.650.500.800 D12.776.377.715.548.680.650.500.795
Concept/Terms	Single-Chain Antibodies Single-Chain Antibodies Antibodies, Single-Chain Single Chain Antibodies ScFv Antibodies Antibodies, ScFv Single-Chain Fv Fv, Single-Chain Single Chain Fv Single-Chain Fv Antibody Antibody, Single-Chain Fv Fv Antibody, Single-Chain Single Chain Fv Antibody Single-Chain Variable Fragment Fragment, Single-Chain Variable Single Chain Variable Fragment Variable Fragment, Single-Chain Single-Chain Variable Fragment Antibodies Single Chain Variable Fragment Antibodies Single-Chain Variable Fragment Antibody Single Chain Variable Fragment Antibody Single-Chain Variable Fragments Fragments, Single-Chain Variable Single Chain Variable Fragments Variable Fragments, Single-Chain Fv Antibody Fragments, Single-Chain Fv Antibody Fragments, Single Chain Single-Chain Fv Antibody Fragments Single Chain Fv Antibody Fragments

Below are MeSH descriptors whose meaning is more general than "Single-Chain Antibodies".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Single-Chain Antibodies [D12.644.541.500.650.500.800]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Antibodies [D12.776.124.486.485.114]
Antibodies, Monoclonal [D12.776.124.486.485.114.224]
Single-Chain Antibodies [D12.776.124.486.485.114.224.785]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Single-Chain Antibodies [D12.776.124.486.485.680.650.500.800]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Single-Chain Antibodies [D12.776.124.790.651.680.650.500.800]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Single-Chain Antibodies [D12.776.377.715.548.680.650.500.795]

Below are MeSH descriptors whose meaning is related to "Single-Chain Antibodies".

Below are MeSH descriptors whose meaning is more specific than "Single-Chain Antibodies".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Single-Chain Antibodies" by people in this website by year, and whether "Single-Chain Antibodies" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	1	0	1
2017	0	1	1
2019	0	1	1
2020	1	0	1
2021	0	2	2
2022	0	1	1
2025	0	1	1
2026	1	0	1

Below are the most recent publications written about "Single-Chain Antibodies" by people in Profiles.

O'Shea CM, Shahzad R, Aghasoleimani K, Newman S, Panmanee J, Schalkwyk LC, Brooke GN, Benson FE, Trimmer JS, Bosco DA, Fujisawa T, Ichijo H, Cashman NR, Engel S, Wright GSA. Reliable repurposing of the antibody interactome inside the cell. Nat Commun. 2026 Jan 31; 17(1).

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Kim J, Shin DW, Lee J, Lee MJ, Yu YG, Lee DH, Kang TH. Engineering Native-like GPCR Antigens Enables Discovery of an LPA2-Blocking Antibody for Ovarian Cancer. ACS Synth Biol. 2026 01 16; 15(1):309-320.

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Fierle JK, Abram-Saliba J, Atsaves V, Brioschi M, de Tiani M, Reichenbach P, Irving M, Coukos G, Dunn SM. A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors. Sci Rep. 2022 01 21; 12(1):1136.

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Fierle JK, Brioschi M, de Tiani M, Wetterwald L, Atsaves V, Abram-Saliba J, Petrova TV, Coukos G, Dunn SM. Soluble trivalent engagers redirect cytolytic T?cell activity toward tumor endothelial marker 1. Cell Rep Med. 2021 08 17; 2(8):100362.

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van de Donk NWCJ, Usmani SZ, Yong K. CAR T-cell therapy for multiple myeloma: state of the art and prospects. Lancet Haematol. 2021 Jun; 8(6):e446-e461.

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D'Onofrio A, Gano L, Melo R, Mendes F, Oliveira MC, Deno?l T, Schaefer N, Viertl D, Fierle J, Coukos G, Dunn S, Prior JO, Paulo A. Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies. Eur J Pharm Biopharm. 2021 Jan; 158:233-244.

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Fierle JK, Abram-Saliba J, Brioschi M, deTiani M, Coukos G, Dunn SM. Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery. Sci Rep. 2019 09 06; 9(1):12815.

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Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839.

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Yu X, Duval M, Gawron M, Posner MR, Cavacini LA. Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition. J Immunol Res. 2016; 2016:9425172.

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Arora SK, Sharma R, Kaur G, Bhoria P, Sharma M, Luthra-Guptasarma M. Towards an indirect screening technique facilitating detection of cellular populations bearing specific cell surface markers. Biotechnol Prog. 2010 Nov-Dec; 26(6):1544-50.

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