Single-Domain Antibodies

"Single-Domain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN or IMMUNOGLOBULIN LIGHT CHAIN.

Descriptor ID	D061905
MeSH Number(s)	D12.644.541.500.650.500.900 D12.776.124.486.485.680.650.500.900 D12.776.124.790.651.680.650.500.900 D12.776.377.715.548.680.650.500.897
Concept/Terms	Single-Domain Antibodies Single-Domain Antibodies Antibodies, Single-Domain Single Domain Antibodies Immunoglobulin VL Domain Fragments Immunoglobulin VL Domain Fragments VL Domain Fragments Domain Fragments, VL Fragments, VL Domain Immunoglobulin VH Domain Fragments Immunoglobulin VH Domain Fragments VH Domain Fragments Domain Fragments, VH Fragments, VH Domain VHH Immunoglobulin Fragments VHH Immunoglobulin Fragments Fragments, VHH Immunoglobulin Immunoglobulin Fragments, VHH Nanobodies VHH Fragments Fragments, VHH VNAR Immunoglobulin Fragments VNAR Immunoglobulin Fragments Fragments, VNAR Immunoglobulin Immunoglobulin Fragments, VNAR VNAR Fragments Fragments, VNAR

Below are MeSH descriptors whose meaning is more general than "Single-Domain Antibodies".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Single-Domain Antibodies [D12.644.541.500.650.500.900]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Single-Domain Antibodies [D12.776.124.486.485.680.650.500.900]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Single-Domain Antibodies [D12.776.124.790.651.680.650.500.900]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Single-Domain Antibodies [D12.776.377.715.548.680.650.500.897]

Below are MeSH descriptors whose meaning is related to "Single-Domain Antibodies".

Below are MeSH descriptors whose meaning is more specific than "Single-Domain Antibodies".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Single-Domain Antibodies" by people in this website by year, and whether "Single-Domain Antibodies" was a major or minor topic of these publications.

Bar chart showing 6 publications over 4 distinct years, with a maximum of 2 publications in 2021 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2017	1	0	1
2021	1	1	2
2022	2	0	2
2024	1	0	1

Below are the most recent publications written about "Single-Domain Antibodies" by people in Profiles.

Vance DJ, Basir S, Piazza CL, Willsey GG, Haque HME, Tremblay JM, Rudolph MJ, Muriuki B, Cavacini L, Weis DD, Shoemaker CB, Mantis NJ. Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA). Infect Immun. 2024 04 09; 92(4):e0008424.

View in: PubMed
Kumar MS, Fowler-Magaw ME, Kulick D, Boopathy S, Gadd DH, Rotunno M, Douthwright C, Golebiowski D, Yusuf I, Xu Z, Brown RH, Sena-Esteves M, O'Neil AL, Bosco DA. Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons. Int J Mol Sci. 2022 Dec 16; 23(24).

View in: PubMed
Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Front Immunol. 2022; 13:995412.

View in: PubMed
Guest JD, Vreven T, Zhou J, Moal I, Jeliazkov JR, Gray JJ, Weng Z, Pierce BG. An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants. Structure. 2021 06 03; 29(6):606-621.e5.

View in: PubMed
Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. Sci Rep. 2021 02 02; 11(1):2751.

View in: PubMed
Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V. A specific nanobody prevents amyloidogenesis of D76N ?2-microglobulin in vitro and modifies its tissue distribution in vivo. Sci Rep. 2017 04 21; 7:46711.

View in: PubMed

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