Antigen Presentation

"Antigen Presentation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)

Descriptor ID	D017951
MeSH Number(s)	G12.119 G12.450.050.400.070
Concept/Terms	Antigen Presentation Antigen Presentation Antigen Presentations Antigen Processing Antigen Processing Antigen Processings

Below are MeSH descriptors whose meaning is more general than "Antigen Presentation".

Biological Sciences [G]
Immune System Phenomena [G12]
Antigen Presentation [G12.119]
Immunity [G12.450]
Adaptive Immunity [G12.450.050]
Immunity, Cellular [G12.450.050.400]
Antigen Presentation [G12.450.050.400.070]

Below are MeSH descriptors whose meaning is related to "Antigen Presentation".

Below are MeSH descriptors whose meaning is more specific than "Antigen Presentation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antigen Presentation" by people in this website by year, and whether "Antigen Presentation" was a major or minor topic of these publications.

Bar chart showing 181 publications over 31 distinct years, with a maximum of 13 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1994	2	1	3
1995	4	0	4
1996	7	3	10
1997	3	0	3
1998	5	4	9
1999	6	4	10
2000	7	2	9
2001	2	2	4
2002	2	2	4
2003	3	4	7
2004	3	5	8
2005	9	4	13
2006	8	2	10
2007	6	5	11
2008	2	5	7
2009	2	2	4
2010	4	4	8
2011	5	1	6
2012	3	3	6
2013	2	1	3
2014	2	3	5
2015	2	0	2
2016	3	4	7
2017	0	1	1
2018	2	3	5
2019	5	5	10
2020	2	0	2
2021	5	2	7
2022	1	0	1
2023	1	0	1

Below are the most recent publications written about "Antigen Presentation" by people in Profiles.

Cruz FM, Chan A, Rock KL. Pathways of MHC I cross-presentation of exogenous antigens. Semin Immunol. 2023 03; 66:101729.

View in: PubMed
Colbert JD, Cruz FM, Baer CE, Rock KL. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Proc Natl Acad Sci U S A. 2022 10 18; 119(42):e2122188119.

View in: PubMed
Swain SL, Jones MC, Devarajan P, Xia J, Dutton RW, Strutt TM, McKinstry KK. Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates. Cold Spring Harb Perspect Biol. 2021 11 01; 13(11).

View in: PubMed
Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Soucy AM, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity. Nat Commun. 2021 10 05; 12(1):5834.

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Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ. Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nat Commun. 2021 09 06; 12(1):5302.

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Nanaware PP, Jurewicz MM, Clement CC, Lu L, Santambrogio L, Stern LJ. Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-Ab in C57BL/6 Mouse Thymus. Front Immunol. 2021; 12:658601.

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Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, Sylvia K, Dasgupta I, Arjomandnejad M, Nixon T, Keeler AM, Manokaran S, He R, Su Q, Tai PWL, Gao G. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction. Front Immunol. 2021; 12:674242.

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Clement CC, Nanaware PP, Yamazaki T, Negroni MP, Ramesh K, Morozova K, Thangaswamy S, Graves A, Kim HJ, Li TW, Vigano' M, Soni RK, Gadina M, Tse HY, Galluzzi L, Roche PA, Denzin LK, Stern LJ, Santambrogio L. Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery. Immunity. 2021 04 13; 54(4):721-736.e10.

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Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation. Front Immunol. 2021; 12:636568.

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Colbert JD, Rock KL. How a tailor achieves the perfect fit. J Biol Chem. 2020 05 22; 295(21):7211-7212.

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