 CpG Islands
"CpG Islands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.
| Descriptor ID |
D018899
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| MeSH Number(s) |
G02.111.570.080.380.160 G05.360.080.380.160 G05.360.340.024.159
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| Concept/Terms |
CpG Islands- CpG Islands
- CpG Island
- Island, CpG
- Islands, CpG
- CpG-Rich Islands
- CpG Rich Islands
- CpG-Rich Island
- Island, CpG-Rich
- Islands, CpG-Rich
CpG Clusters- CpG Clusters
- Cluster, CpG
- Clusters, CpG
- CpG Cluster
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Below are MeSH descriptors whose meaning is more general than "CpG Islands".
Below are MeSH descriptors whose meaning is more specific than "CpG Islands".
This graph shows the total number of publications written about "CpG Islands" by people in this website by year, and whether "CpG Islands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 0 | 3 | | 1997 | 5 | 0 | 5 | | 1998 | 8 | 1 | 9 | | 1999 | 11 | 1 | 12 | | 2000 | 13 | 1 | 14 | | 2001 | 11 | 3 | 14 | | 2002 | 5 | 4 | 9 | | 2003 | 7 | 6 | 13 | | 2004 | 8 | 2 | 10 | | 2005 | 2 | 3 | 5 | | 2006 | 2 | 6 | 8 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 3 | 4 | | 2009 | 1 | 3 | 4 | | 2010 | 2 | 5 | 7 | | 2011 | 1 | 3 | 4 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 5 | 5 | | 2014 | 2 | 3 | 5 | | 2015 | 1 | 4 | 5 |
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Below are the most recent publications written about "CpG Islands" by people in Profiles.
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Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, Suvà ML, Bernstein BE. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature. 2016 Jan 07; 529(7584):110-4.
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Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, Jørgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barrès R. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2016 Feb 09; 23(2):369-78.
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Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015 Dec; 25(12):1801-11.
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Schafer DP, Stevens B. Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages. Immunity. 2015 Apr 21; 42(4):600-2.
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Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, Smirnov I, Baker W, Norris GT, Marin I, Coddington N, Wolf Y, Turner SD, Aderem A, Klibanov AL, Harris TH, Jung S, Litvak V, Kipnis J. Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity. 2015 Apr 21; 42(4):679-91.
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Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM. Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics. 2015; 10(6):545-61.
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Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014 Sep 18; 55(6):904-15.
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de Faria PC, dos Santos LI, Coelho JP, Ribeiro HB, Pimenta MA, Ladeira LO, Gomes DA, Furtado CA, Gazzinelli RT. Oxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8(+) T cell response and protection against cancer. Nano Lett. 2014 Sep 10; 14(9):5458-70.
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Yildirim O, Hung JH, Cedeno RJ, Weng Z, Lengner CJ, Rando OJ. A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters. PLoS Genet. 2014 Aug; 10(8):e1004515.
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Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12; 3:e02313.
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