Focal Adhesion Kinase 2

"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.

Descriptor ID	D051418
MeSH Number(s)	D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
Concept/Terms	Focal Adhesion Kinase 2 Focal Adhesion Kinase 2 RAFTK Protein Cell Adhesion Kinase Beta Proline-Rich Tyrosine Kinase 2 Proline Rich Tyrosine Kinase 2 Related Adhesion Focal Tyrosine Kinase CADTK Protein Focal Adhesion Kinase Autokinase FAK Autokinase Calcium-Dependent Protein Tyrosine Kinase Calcium Dependent Protein Tyrosine Kinase PYK2 Protein Tyrosine Kinase Protein Tyrosine Kinase PYK2

Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]
Focal Adhesion Kinase 2 [D08.811.913.696.620.682.725.049.750]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Minor Histocompatibility Antigens [D23.050.301.500.600]
Focal Adhesion Kinase 2 [D23.050.301.500.600.350]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Minor Histocompatibility Antigens [D23.050.705.552.600]
Focal Adhesion Kinase 2 [D23.050.705.552.600.350]

Below are MeSH descriptors whose meaning is related to "Focal Adhesion Kinase 2".

Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2000 and 2005 and 2012 and 2014 and 2016 and 2018 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2005	0	1	1
2012	0	1	1
2014	1	0	1
2016	0	1	1
2018	0	1	1
2023	0	1	1

Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.

Zheng L, Spagnol G, Gandhi DR, Sharma K, Kumar V, Patel KP, Sorgen PL. Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure. Circ Heart Fail. 2023 08; 16(8):e010294.

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Matamoros-Volante A, Moreno-Irusta A, Torres-Rodriguez P, Giojalas L, Gervasi MG, Visconti PE, Trevi?o CL. Semi-automatized segmentation method using image-based flow cytometry to study sperm physiology: the case of capacitation-induced tyrosine phosphorylation. Mol Hum Reprod. 2018 02 01; 24(2):64-73.

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Alvau A, Battistone MA, Gervasi MG, Navarrete FA, Xu X, S?nchez-C?rdenas C, De la Vega-Beltran JL, Da Ros VG, Greer PA, Darszon A, Krapf D, Salicioni AM, Cuasnicu PS, Visconti PE. The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm. Development. 2016 07 01; 143(13):2325-33.

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Battistone MA, Alvau A, Salicioni AM, Visconti PE, Da Ros VG, Cuasnic? PS. Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation. Mol Hum Reprod. 2014 Nov; 20(11):1054-66.

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Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20.

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Sekimoto H, Eipper-Mains J, Pond-Tor S, Boney CM. (alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells. Mol Endocrinol. 2005 Jul; 19(7):1859-67.

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Rocic P, Griffin TM, McRae CN, Lucchesi PA. Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H457-65.

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Park JG, Bose A, Leszyk J, Czech MP. PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters. J Biol Chem. 2001 Dec 21; 276(51):47751-4.

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Litvak V, Tian D, Shaul YD, Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. J Biol Chem. 2000 Oct 20; 275(42):32736-46.

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Tian D, Litvak V, Lev S. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. J Neurosci. 2000 Sep 01; 20(17):6478-87.

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