Complement C3 Convertase, Alternative Pathway
"Complement C3 Convertase, Alternative Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine protease that is the complex of COMPLEMENT C3B and COMPLEMENT FACTOR BB. It cleaves multiple COMPLEMENT C3 into COMPLEMENT C3A (anaphylatoxin) and COMPLEMENT C3B in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY.
| Descriptor ID |
D051561
|
| MeSH Number(s) |
D12.776.124.486.274.045.387.500.374
|
| Concept/Terms |
Complement C3 Convertase, Alternative Pathway- Complement C3 Convertase, Alternative Pathway
- Complement 3 Convertase, Alternative Pathway
- C3 Convertase (C3bBb)
- Alternative Pathway C3 Convertase
- C3 Convertase, Alternative Pathway
- Complement 3b-Associated Factor B-fragment Bb
- Complement 3b Associated Factor B fragment Bb
|
Below are MeSH descriptors whose meaning is more general than "Complement C3 Convertase, Alternative Pathway".
Below are MeSH descriptors whose meaning is more specific than "Complement C3 Convertase, Alternative Pathway".
This graph shows the total number of publications written about "Complement C3 Convertase, Alternative Pathway" by people in this website by year, and whether "Complement C3 Convertase, Alternative Pathway" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C3 Convertase, Alternative Pathway" by people in Profiles.
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Fridkis-Hareli M, Storek M, Or E, Altman R, Katti S, Sun F, Peng T, Hunter J, Johnson K, Wang Y, Lundberg AS, Mehta G, Banda NK, Michael Holers V. The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models. Mol Immunol. 2019 01; 105:150-164.
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Blom AM, Magda M, Kohl L, Shaughnessy J, Lambris JD, Ram S, Ermert D. Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes. J Immunol. 2017 12 01; 199(11):3828-3839.
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Agarwal S, Ferreira VP, Cortes C, Pangburn MK, Rice PA, Ram S. An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. J Immunol. 2010 Jul 01; 185(1):507-16.