Immunoglobulin Switch Region
"Immunoglobulin Switch Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Descriptor ID |
D007134
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MeSH Number(s) |
G05.360.340.024.340.137.430 G05.360.340.024.340.335.300.500
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Concept/Terms |
Immunoglobulin Switch Region- Immunoglobulin Switch Region
- Ig Switch Sequences
- Ig Switch Sequence
- Sequence, Ig Switch
- Sequences, Ig Switch
- Switch Sequence, Ig
- Switch Sequences, Ig
- Switch Region, Immunoglobulin
- Immunoglobulin Switch Regions
- Region, Immunoglobulin Switch
- Regions, Immunoglobulin Switch
- Switch Regions, Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Switch Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Switch Region".
This graph shows the total number of publications written about "Immunoglobulin Switch Region" by people in this website by year, and whether "Immunoglobulin Switch Region" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 1 | 0 | 1 |
2001 | 1 | 0 | 1 |
2002 | 1 | 0 | 1 |
2003 | 1 | 0 | 1 |
2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2009 | 2 | 0 | 2 |
2011 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Switch Region" by people in Profiles.
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Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J. Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS One. 2015; 10(8):e0134397.
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Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J. AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol. 2011 Sep 01; 187(5):2464-75.
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Eccleston J, Schrader CE, Yuan K, Stavnezer J, Selsing E. Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J Immunol. 2009 Jul 15; 183(2):1222-8.
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Schrader CE, Guikema JE, Wu X, Stavnezer J. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):645-52.
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Wu X, Stavnezer J. DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination. J Exp Med. 2007 Jul 09; 204(7):1677-89.
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Min IM, Rothlein LR, Schrader CE, Stavnezer J, Selsing E. Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J Exp Med. 2005 Jun 20; 201(12):1885-90.
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Kaminski DA, Stavnezer J. Antibody class switching: uncoupling S region accessibility from transcription. Trends Genet. 2004 Aug; 20(8):337-40.
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Schrader CE, Bradley SP, Vardo J, Mochegova SN, Flanagan E, Stavnezer J. Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. EMBO J. 2003 Nov 03; 22(21):5893-903.
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Drouin EE, Schrader CE, Stavnezer J, Hansen U. The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA. J Immunol. 2002 Mar 15; 168(6):2847-56.
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Luby TM, Schrader CE, Stavnezer J, Selsing E. The mu switch region tandem repeats are important, but not required, for antibody class switch recombination. J Exp Med. 2001 Jan 15; 193(2):159-68.