Sialic Acids

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"Sialic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.

Descriptor ID	D012794
MeSH Number(s)	D02.241.081.844.562.668 D02.241.511.902.562.668 D09.067.687.668 D09.811.589.668
Concept/Terms	Sialic Acids Sialic Acids Acids, Sialic N-Acetylneuraminic Acids Acids, N-Acetylneuraminic N Acetylneuraminic Acids

Below are MeSH descriptors whose meaning is more general than "Sialic Acids".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Carboxylic Acids [D02.241]
Acids, Acyclic [D02.241.081]
Sugar Acids [D02.241.081.844]
Neuraminic Acids [D02.241.081.844.562]
Sialic Acids [D02.241.081.844.562.668]
Hydroxy Acids [D02.241.511]
Sugar Acids [D02.241.511.902]
Neuraminic Acids [D02.241.511.902.562]
Sialic Acids [D02.241.511.902.562.668]
Carbohydrates [D09]
Amino Sugars [D09.067]
Neuraminic Acids [D09.067.687]
Sialic Acids [D09.067.687.668]
Sugar Acids [D09.811]
Neuraminic Acids [D09.811.589]
Sialic Acids [D09.811.589.668]

Below are MeSH descriptors whose meaning is related to "Sialic Acids".

Below are MeSH descriptors whose meaning is more specific than "Sialic Acids".

Sialic Acids
Cytidine Monophosphate N-Acetylneuraminic Acid
N-Acetylneuraminic Acid
Zanamivir

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sialic Acids" by people in this website by year, and whether "Sialic Acids" was a major or minor topic of these publications.

Bar chart showing 20 publications over 12 distinct years, with a maximum of 4 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
1999	0	1	1
2004	0	1	1
2007	1	0	1
2008	0	1	1
2012	1	0	1
2013	2	0	2
2015	2	2	4
2016	1	1	2
2017	1	0	1
2020	2	1	3
2021	1	0	1

Below are the most recent publications written about "Sialic Acids" by people in Profiles.

Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, M?nster-K?hnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 2021 01 19; 12(1).

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Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins. J Infect Dis. 2020 10 13; 222(10):1641-1650.

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Awasthi M, Gulati S, Sarkar DP, Tiwari S, Kateriya S, Ranjan P, Verma SK. The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV. Viruses. 2020 08 19; 12(9).

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Gulati S, Schoenhofen IC, Lindhout-Djukic T, Schur MJ, Landig CS, Saha S, Deng L, Lewis LA, Zheng B, Varki A, Ram S. Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae. J Immunol. 2020 06 15; 204(12):3283-3295.

View in: PubMed
Ram S, Shaughnessy J, de Oliveira RB, Lewis LA, Gulati S, Rice PA. Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics. Pathog Dis. 2017 06 01; 75(4).

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Ram S, Shaughnessy J, DeOliveira RB, Lewis LA, Gulati S, Rice PA. Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. Immunobiology. 2016 10; 221(10):1110-23.

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van Karnebeek CD, Bonaf? L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier-Daire V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K, Rozmus J, Harshman K, Stevenson BJ, Girardi E, Superti-Furga G, Dewan T, Collingridge A, Halparin J, Ross CJ, Van Allen MI, Rossi A, Engelke UF, Kluijtmans LA, van der Heeft E, Renkema H, de Brouwer A, Huijben K, Zijlstra F, Heise T, Boltje T, Wasserman WW, Rivolta C, Unger S, Lefeber DJ, Wevers RA, Superti-Furga A. NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet. 2016 07; 48(7):777-84.

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Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, Reed GW, Varki A, Rice PA, Ram S. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. PLoS Pathog. 2015 Dec; 11(12):e1005290.

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Str?h LJ, Gee GV, Blaum BS, Dugan AS, Feltkamp MC, Atwood WJ, Stehle T. Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids. PLoS Pathog. 2015 Aug; 11(8):e1005112.

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Str?h LJ, Maginnis MS, Blaum BS, Nelson CD, Neu U, Gee GV, O'Hara BA, Motamedi N, DiMaio D, Atwood WJ, Stehle T. The Greater Affinity of JC Polyomavirus Capsid for a2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity. J Virol. 2015 Jun; 89(12):6364-75.

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