N-Acetylneuraminic Acid

"N-Acetylneuraminic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)

Descriptor ID	D019158
MeSH Number(s)	D02.241.081.844.562.668.050 D02.241.511.902.562.668.050 D09.067.687.668.030 D09.811.589.668.030
Concept/Terms	N-Acetylneuraminic Acid N-Acetylneuraminic Acid Acid, N-Acetylneuraminic N Acetylneuraminic Acid Sialic Acid Acid, Sialic

Below are MeSH descriptors whose meaning is more general than "N-Acetylneuraminic Acid".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Carboxylic Acids [D02.241]
Acids, Acyclic [D02.241.081]
Sugar Acids [D02.241.081.844]
Neuraminic Acids [D02.241.081.844.562]
Sialic Acids [D02.241.081.844.562.668]
N-Acetylneuraminic Acid [D02.241.081.844.562.668.050]
Hydroxy Acids [D02.241.511]
Sugar Acids [D02.241.511.902]
Neuraminic Acids [D02.241.511.902.562]
Sialic Acids [D02.241.511.902.562.668]
N-Acetylneuraminic Acid [D02.241.511.902.562.668.050]
Carbohydrates [D09]
Amino Sugars [D09.067]
Neuraminic Acids [D09.067.687]
Sialic Acids [D09.067.687.668]
N-Acetylneuraminic Acid [D09.067.687.668.030]
Sugar Acids [D09.811]
Neuraminic Acids [D09.811.589]
Sialic Acids [D09.811.589.668]
N-Acetylneuraminic Acid [D09.811.589.668.030]

Below are MeSH descriptors whose meaning is related to "N-Acetylneuraminic Acid".

Below are MeSH descriptors whose meaning is more specific than "N-Acetylneuraminic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "N-Acetylneuraminic Acid" by people in this website by year, and whether "N-Acetylneuraminic Acid" was a major or minor topic of these publications.

Bar chart showing 26 publications over 17 distinct years, with a maximum of 3 publications in 2005 and 2006 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2004	1	0	1
2005	0	3	3
2006	2	1	3
2007	1	0	1
2008	0	1	1
2009	1	1	2
2010	0	1	1
2011	3	0	3
2018	1	1	2
2019	0	1	1
2020	1	1	2
2021	1	0	1
2022	0	1	1
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "N-Acetylneuraminic Acid" by people in Profiles.

D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 Jul 19; 10(29):eadk4920.

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Morrill SR, Saha S, Varki AP, Lewis WG, Ram S, Lewis AL. Gardnerella Vaginolysin Potentiates Glycan Molecular Mimicry by Neisseria gonorrhoeae. J Infect Dis. 2023 11 28; 228(11):1610-1620.

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Burle-Caldas GA, Dos Santos NSA, de Castro JT, Mugge FLB, Grazielle-Silva V, Oliveira AER, Pereira MCA, Reis-Cunha JL, Dos Santos AC, Gomes DA, Bartholomeu DC, Moretti NS, Schenkman S, Gazzinelli RT, Teixeira SMR. Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites. mBio. 2022 02 22; 13(1):e0347821.

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Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, M?nster-K?hnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 2021 01 19; 12(1).

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Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins. J Infect Dis. 2020 10 13; 222(10):1641-1650.

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Awasthi M, Gulati S, Sarkar DP, Tiwari S, Kateriya S, Ranjan P, Verma SK. The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV. Viruses. 2020 08 19; 12(9).

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Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019; 180(2):91-102.

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Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, Rice PA. A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity. Infect Immun. 2018 08; 86(8).

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Luo X, Liu M, Hu L, Qiu Q, Liu X, Li C, Lu M, Liu Y, Zhang T, Zhou S, McClements DJ, Jia X, Deng Y, Song Y. Targeted delivery of pixantrone to neutrophils by poly(sialic acid)-p-octadecylamine conjugate modified liposomes with improved antitumor activity. Int J Pharm. 2018 Aug 25; 547(1-2):315-329.

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Nakatani F, Morita YS, Ashida H, Nagamune K, Maeda Y, Kinoshita T. Identification of a second catalytically active trans-sialidase in Trypanosoma brucei. Biochem Biophys Res Commun. 2011 Nov 18; 415(2):421-5.

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