N-Acetylneuraminic Acid

"N-Acetylneuraminic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)

Descriptor ID	D019158
MeSH Number(s)	D02.241.081.844.562.668.050 D02.241.511.902.562.668.050 D09.067.687.668.030 D09.811.589.668.030
Concept/Terms	N-Acetylneuraminic Acid N-Acetylneuraminic Acid Acid, N-Acetylneuraminic N Acetylneuraminic Acid Sialic Acid Acid, Sialic

Below are MeSH descriptors whose meaning is more general than "N-Acetylneuraminic Acid".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Carboxylic Acids [D02.241]
Acids, Acyclic [D02.241.081]
Sugar Acids [D02.241.081.844]
Neuraminic Acids [D02.241.081.844.562]
Sialic Acids [D02.241.081.844.562.668]
N-Acetylneuraminic Acid [D02.241.081.844.562.668.050]
Hydroxy Acids [D02.241.511]
Sugar Acids [D02.241.511.902]
Neuraminic Acids [D02.241.511.902.562]
Sialic Acids [D02.241.511.902.562.668]
N-Acetylneuraminic Acid [D02.241.511.902.562.668.050]
Carbohydrates [D09]
Amino Sugars [D09.067]
Neuraminic Acids [D09.067.687]
Sialic Acids [D09.067.687.668]
N-Acetylneuraminic Acid [D09.067.687.668.030]
Sugar Acids [D09.811]
Neuraminic Acids [D09.811.589]
Sialic Acids [D09.811.589.668]
N-Acetylneuraminic Acid [D09.811.589.668.030]

Below are MeSH descriptors whose meaning is related to "N-Acetylneuraminic Acid".

Below are MeSH descriptors whose meaning is more specific than "N-Acetylneuraminic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "N-Acetylneuraminic Acid" by people in this website by year, and whether "N-Acetylneuraminic Acid" was a major or minor topic of these publications.

Bar chart showing 27 publications over 18 distinct years, with a maximum of 3 publications in 2006 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2004	1	0	1
2005	0	2	2
2006	2	1	3
2007	1	0	1
2008	0	1	1
2009	1	1	2
2010	0	1	1
2011	2	0	2
2018	1	1	2
2019	0	1	1
2020	1	0	1
2021	1	0	1
2022	1	1	2
2023	0	1	1
2024	1	0	1
2025	3	0	3

Below are the most recent publications written about "N-Acetylneuraminic Acid" by people in Profiles.

Kurt-Jones EA, Gulati S, King M, de Oliveira RB, Rice PA, Zheng B, Shaughnessy J, Edwards JL, Hertzog PJ, Ram S, Golenbock DT. Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. Cell Host Microbe. 2025 Jul 09; 33(7):1133-1145.e4.

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Swan J, Toomey CB, Bergstrand M, Cuello HA, Robie J, Yu H, Yuan Y, Kooner AS, Chen X, Shaughnessy J, Ram S, Varki A, Gagneux P. The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H. Invest Ophthalmol Vis Sci. 2025 Jun 02; 66(6):81.

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Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2426427122.

View in: PubMed
D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 07 19; 10(29):eadk4920.

View in: PubMed
Morrill SR, Saha S, Varki AP, Lewis WG, Ram S, Lewis AL. Gardnerella Vaginolysin Potentiates Glycan Molecular Mimicry by Neisseria gonorrhoeae. J Infect Dis. 2023 11 28; 228(11):1610-1620.

View in: PubMed
Petitpas K, Habibabady Z, Ritchie V, Connolly MR, Burdorf L, Qin W, Kan Y, Layer JV, Crabtree JN, Youd ME, Westlin WF, Magnani DM, Pierson RN, Azimzadeh AM. Genetic modifications designed for xenotransplantation attenuate sialoadhesin-dependent binding of human erythrocytes to porcine macrophages. Xenotransplantation. 2022 11; 29(6):e12780.

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Burle-Caldas GA, Dos Santos NSA, de Castro JT, Mugge FLB, Grazielle-Silva V, Oliveira AER, Pereira MCA, Reis-Cunha JL, Dos Santos AC, Gomes DA, Bartholomeu DC, Moretti NS, Schenkman S, Gazzinelli RT, Teixeira SMR. Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites. mBio. 2022 02 22; 13(1):e0347821.

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Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, M?nster-K?hnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 2021 01 19; 12(1).

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Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins. J Infect Dis. 2020 10 13; 222(10):1641-1650.

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Awasthi M, Gulati S, Sarkar DP, Tiwari S, Kateriya S, Ranjan P, Verma SK. The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV. Viruses. 2020 08 19; 12(9).

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