Cryoelectron Microscopy

"Cryoelectron Microscopy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.

Descriptor ID	D020285
MeSH Number(s)	E01.370.350.515.402.150 E05.595.402.150
Concept/Terms	Cryoelectron Microscopy Cryoelectron Microscopy Cryoelectron Microscopies Microscopies, Cryoelectron Microscopy, Cryoelectron Electron Cryomicroscopy Cryomicroscopies, Electron Cryomicroscopy, Electron Electron Cryomicroscopies Cryo-electron Microscopy Cryo electron Microscopy Cryo-electron Microscopies Microscopies, Cryo-electron Microscopy, Cryo-electron

Below are MeSH descriptors whose meaning is more general than "Cryoelectron Microscopy".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Diagnosis [E01]
Diagnostic Techniques and Procedures [E01.370]
Diagnostic Imaging [E01.370.350]
Microscopy [E01.370.350.515]
Microscopy, Electron [E01.370.350.515.402]
Cryoelectron Microscopy [E01.370.350.515.402.150]
Investigative Techniques [E05]
Microscopy [E05.595]
Microscopy, Electron [E05.595.402]
Cryoelectron Microscopy [E05.595.402.150]

Below are MeSH descriptors whose meaning is related to "Cryoelectron Microscopy".

Below are MeSH descriptors whose meaning is more specific than "Cryoelectron Microscopy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cryoelectron Microscopy" by people in this website by year, and whether "Cryoelectron Microscopy" was a major or minor topic of these publications.

Bar chart showing 143 publications over 26 distinct years, with a maximum of 13 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2002	0	2	2
2003	2	1	3
2004	2	2	4
2005	0	1	1
2006	2	0	2
2007	2	1	3
2008	1	4	5
2009	1	3	4
2010	1	4	5
2011	3	3	6
2012	2	3	5
2013	1	2	3
2014	0	2	2
2015	7	2	9
2016	2	5	7
2017	3	6	9
2018	3	6	9
2019	1	9	10
2020	2	11	13
2021	3	7	10
2022	1	9	10
2023	1	5	6
2024	2	5	7
2025	3	3	6

Below are the most recent publications written about "Cryoelectron Microscopy" by people in Profiles.

Dingeldein L, Silva-S?nchez D, Evans L, D'Imprima E, Grigorieff N, Covino R, Cossio P. Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference. Proc Natl Acad Sci U S A. 2025 Jun 10; 122(23):e2420158122.

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Liu Y, Brown CM, Borges N, Nobre RN, Erramilli S, Belcher Dufrisne M, Kloss B, Giacometti S, Esteves AM, Tim?teo CG, Tokarz P, Cater RJ, Lowary TL, Morita YS, Kossiakoff AA, Santos H, Stansfeld PJ, Nygaard R, Mancia F. Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. Nat Commun. 2025 Apr 29; 16(1):3974.

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Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2426427122.

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Woollard G, Zhou W, Thiede EH, Lin C, Grigorieff N, Cossio P, Dao Duc K, Hanson SM. InstaMap: instant-NGP for cryo-EM density maps. Acta Crystallogr D Struct Biol. 2025 Apr 01; 81(Pt 4):147-169.

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Zhang K, Cossio P, Rangan AV, Lucas BA, Grigorieff N. A new statistical metric for robust target detection in cryo-EM using 2D template matching. IUCrJ. 2025 Mar 01; 12(Pt 2):155-176.

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M'Angale PG, Lemieux A, Liu Y, Wang S, Zinter M, Alegre G, Simkin A, Budnik V, Kelch BA, Thomson T. Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. PLoS Biol. 2025 Feb; 23(2):e3002983.

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Elferich J, Kong L, Zottig X, Grigorieff N. CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples. Elife. 2024 Dec 20; 13.

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Matsui A, Spangler C, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E. Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses. Elife. 2024 Nov 04; 13.

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Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, McKee K, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S. Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains. Nat Commun. 2024 May 21; 15(1):4301.

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Loveland AB, Koh CS, Ganesan R, Jacobson A, Korostelev AA. Structural mechanism of angiogenin activation by the ribosome. Nature. 2024 Jun; 630(8017):769-776.

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