 Integrin beta4
"Integrin beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.
| Descriptor ID |
D039663
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| MeSH Number(s) |
D12.776.543.750.705.408.200.800 D23.050.301.264.035.303 D23.101.100.110.302
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| Concept/Terms |
Integrin beta4- Integrin beta4
- beta4, Integrin
- beta4 Integrin
- Integrin, beta4
- CD104 Antigens
- Antigens, CD104
- CD104 Antigen
- Antigen, CD104
- Integrin beta(4)
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Below are MeSH descriptors whose meaning is more general than "Integrin beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin beta4".
This graph shows the total number of publications written about "Integrin beta4" by people in this website by year, and whether "Integrin beta4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin beta4" by people in Profiles.
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Li J, Sun H, Feltri ML, Mercurio AM. Integrin ß4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15; 407(2):313-20.
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Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38a MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 2; 290(1):284-95.
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Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ß4. FASEB J. 2015 Jan; 29(1):131-40.
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Chang C, Yang X, Pursell B, Mercurio AM. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ß4. Mol Cell Biol. 2013 Oct; 33(19):3795-804.
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Wang L, Pawlak EA, Johnson PJ, Belknap JK, Eades S, Stack S, Cousin H, Black SJ. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One. 2013; 8(2):e56025.
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Gerson KD, Shearstone JR, Maddula VS, Seligmann BE, Mercurio AM. Integrin ß4 regulates SPARC protein to promote invasion. J Biol Chem. 2012 Mar 23; 287(13):9835-44.
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Kashyap T, Germain E, Roche M, Lyle S, Rabinovitz I. Role of ß4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Lab Invest. 2011 Oct; 91(10):1414-26.
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Yang X, Pursell B, Lu S, Chang TK, Mercurio AM. Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci. 2009 Jul 15; 122(Pt 14):2473-80.
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Salvestrini C, McGrath JA, Ozoemena L, Husain K, Buhamrah E, Sabery N, Leichtner A, Rufo PA, Perez-Atayde A, Orteu CH, Torrente F, Heuschkel RB, Thomson MA, Murch SH. Desquamative enteropathy and pyloric atresia without skin disease caused by a novel intracellular beta4 integrin mutation. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):585-91.
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Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8.
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