Protein Kinase C-alpha

"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

Descriptor ID	D051571
MeSH Number(s)	D08.811.913.696.620.682.700.725.100
Concept/Terms	Protein Kinase C-alpha Protein Kinase C-alpha Protein Kinase C(alpha) PKC-alpha Serine-Threonine Kinase PKC alpha Serine Threonine Kinase Serine-Threonine Kinase, PKC-alpha Protein Kinase C alpha

Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Protein Kinase C [D08.811.913.696.620.682.700.725]
Protein Kinase C-alpha [D08.811.913.696.620.682.700.725.100]

Below are MeSH descriptors whose meaning is related to "Protein Kinase C-alpha".

Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in this website by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.

Bar chart showing 16 publications over 8 distinct years, with a maximum of 5 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	2	2
2003	0	1	1
2004	0	5	5
2006	1	0	1
2011	2	2	4
2014	0	1	1
2016	0	1	1
2018	1	0	1

Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles.

Hu R, Morley MP, Brandimarto J, Tucker NR, Parsons VA, Zhao SD, Meder B, Katus HA, R?hle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, Vasan RS, van der Harst P, Newton-Cheh C, Li J, Kim CE, Hakonarson H, Hannenhalli S, Ashley EA, Moravec CS, Tang WHW, Maillet M, Molkentin JD, Ellinor PT, Margulies KB, Cappola TP. Genetic Reduction in Left Ventricular Protein Kinase C-a and Adverse Ventricular Remodeling in Human Subjects. Circ Genom Precis Med. 2018 03; 11(3):e001901.

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Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 05 24; 15(8):1728-42.

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Bailey KL, Bonasera SJ, Wilderdyke M, Hanisch BW, Pavlik JA, DeVasure J, Robinson JE, Sisson JH, Wyatt TA. Aging causes a slowing in ciliary beat frequency, mediated by PKCe. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15; 306(6):L584-9.

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Guo D, Standley C, Bellve K, Fogarty K, Bao ZZ. Protein kinase Ca and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Mol Cell Neurosci. 2012 May; 50(1):82-92.

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Maharaj NP, Wies E, Stoll A, Gack MU. Conventional protein kinase C-a (PKC-a) and PKC-? negatively regulate RIG-I antiviral signal transduction. J Virol. 2012 Feb; 86(3):1358-71.

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Agbor TA, Demma ZC, Mumy KL, Bien JD, McCormick BA. The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection. Cell Microbiol. 2011 Dec; 13(12):2007-21.

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Arora S, Ranade AR, Tran NL, Nasser S, Sridhar S, Korn RL, Ross JT, Dhruv H, Foss KM, Sibenaller Z, Ryken T, Gotway MB, Kim S, Weiss GJ. MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. Int J Cancer. 2011 Dec 01; 129(11):2621-31.

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Stewart MD, Morgan B, Massi F, Igumenova TI. Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Ca. J Mol Biol. 2011 May 20; 408(5):949-70.

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Coaxum SD, Griffin TM, Martin JL, Mestril R. Influence of PKC-alpha overexpression on HSP70 and cardioprotection. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2220-6.

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Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec; 11(6):859-71.

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