Binding Sites

"Binding Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Descriptor ID	D001665
MeSH Number(s)	G02.111.570.120
Concept/Terms	Binding Sites Binding Sites Site, Binding Sites, Binding Binding Site Combining Site Combining Sites Site, Combining Sites, Combining

Below are MeSH descriptors whose meaning is more general than "Binding Sites".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Binding Sites [G02.111.570.120]

Below are MeSH descriptors whose meaning is related to "Binding Sites".

Below are MeSH descriptors whose meaning is more specific than "Binding Sites".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Binding Sites" by people in this website by year, and whether "Binding Sites" was a major or minor topic of these publications.

Bar chart showing 716 publications over 31 distinct years, with a maximum of 45 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	9	9
1997	0	12	12
1998	0	11	11
1999	1	14	15
2000	0	24	24
2001	0	18	18
2002	0	45	45
2003	0	30	30
2004	0	31	31
2005	0	35	35
2006	0	27	27
2007	0	32	32
2008	0	40	40
2009	0	32	32
2010	1	29	30
2011	0	37	37
2012	1	41	42
2013	1	33	34
2014	0	27	27
2015	0	31	31
2016	0	19	19
2017	0	23	23
2018	0	26	26
2019	0	16	16
2020	0	18	18
2021	0	14	14
2022	0	5	5
2023	0	5	5
2024	0	11	11
2025	0	12	12
2026	0	5	5

Below are the most recent publications written about "Binding Sites" by people in Profiles.

Elhajjajy SI, Weng Z. A novel NLP-based method and algorithm to discover RNA-binding protein (RBP) motifs, contexts, binding preferences, and interactions. RNA. 2026 May 18; 32(6):885-914.

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Bhasne K, D?rries L, Maqtedar A, Mager ST, Clerico EM, Gierasch LM. Model Peptides Enable Comparisons of Substrate Binding Modes of Hsp70 Molecular Chaperones. Biochemistry. 2026 Apr 21; 65(8):1214-1223.

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Vega-Badillo J, Zamore PD, Jouravleva K. Biochemical principles of miRNA targeting in flies. Nat Commun. 2026 Jan 20; 17(1):1641.

View in: PubMed
Maqtedar A, Rossi MA, Clerico EM, Williams RV, Gierasch LM. The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate-binding domain. J Biol Chem. 2026 Mar; 302(3):111176.

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Raza M, Haspel N, Sharma A, Choi SH, De Luna X, Evans JJ. Evaluation of CendR peptides mined from protein databases as potential inhibitors of neuropilin-1 using an in-silico molecular modeling approach. J Mol Graph Model. 2026 May; 144:109279.

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D?az-Salinas MA, Benlarbi M, Chatterjee D, Nayrac M, Robidas M, Pinyakorn S, Phanuphak N, Sacdalan C, Medjahed H, Pr?vost J, Trautmann L, Pazgier M, Finzi A, Munro JB. Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity. J Virol. 2026 01 20; 100(1):e0166725.

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Richard J, Grunst MW, Niu L, D?az-Salinas MA, Zhu L, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Kim H, Boodapati SLT, Yang D, Chiu TJ, Chen HC, Benlarbi M, Beaudoin-Bussi?res G, Gottumukkala S, Li W, Dionne K, B?langer ?, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB, Kumar P, Mothes W, Munro JB, Pazgier M, Finzi A. The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC. Nat Commun. 2025 Dec 01; 16(1):10419.

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Maryam A, Moquin SA, Dovala D, Kaur J, Kurt Yilmaz N, Shaqra AM, Schiffer CA. Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease. Viruses. 2025 Nov 16; 17(11).

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Intravaia LE, Shaqra AM, Pirhadi S, Popko N, Kurt Yilmaz N, Schiffer CA. Predicting the Impact of Drug Resistance Mutations on Inhibitor Potency with Molecular Dynamics and Machine Learning. J Phys Chem B. 2025 10 30; 129(43):11128-11140.

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Webb J, Liew JJM, Gnann AD, Ilkhani K, Patterson M, Paul S, For?s M, Jim?nez G, Veraksa A, Dowling DP. Molecular basis of DNA recognition by the HMG-box-C1 module of capicua. Structure. 2025 Dec 04; 33(12):2109-2121.e5.

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