 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1989 | 1 | 1 | 2 | | 1990 | 2 | 0 | 2 | | 1991 | 3 | 4 | 7 | | 1992 | 5 | 2 | 7 | | 1993 | 4 | 5 | 9 | | 1994 | 9 | 5 | 14 | | 1995 | 4 | 6 | 10 | | 1996 | 5 | 5 | 10 | | 1997 | 8 | 4 | 12 | | 1998 | 4 | 3 | 7 | | 1999 | 3 | 3 | 6 | | 2000 | 8 | 4 | 12 | | 2001 | 3 | 11 | 14 | | 2002 | 10 | 4 | 14 | | 2003 | 12 | 2 | 14 | | 2004 | 11 | 6 | 17 | | 2005 | 15 | 11 | 26 | | 2006 | 11 | 15 | 26 | | 2007 | 12 | 17 | 29 | | 2008 | 14 | 13 | 27 | | 2009 | 13 | 8 | 21 | | 2010 | 14 | 6 | 20 | | 2011 | 10 | 7 | 17 | | 2012 | 15 | 9 | 24 | | 2013 | 14 | 8 | 22 | | 2014 | 10 | 7 | 17 | | 2015 | 8 | 8 | 16 | | 2016 | 2 | 0 | 2 | | 2017 | 3 | 3 | 6 | | 2018 | 1 | 3 | 4 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Baptista AP, Gola A, Huang Y, Milanez-Almeida P, Torabi-Parizi P, Urban JF, Shapiro VS, Gerner MY, Germain RN. The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity. 2019 05 21; 50(5):1188-1201.e6.
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Sivay MV, Fogel JM, Wang J, Zhang Y, Piwowar-Manning E, Clarke W, Breaud A, Blankson J, Hamilton EL, Kahn K, Selin A, Gomez-Olive FX, MacPhail C, Hughes JP, Pettifor A, Eshleman SH. Natural control of HIV infection in young women in South Africa: HPTN 068. HIV Clin Trials. 2018 10; 19(5):202-208.
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Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF, Blazar BR, Elliott DE, Ince MN. Helminth-Induced Production of TGF-ß and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells. J Immunol. 2018 11 15; 201(10):2910-2922.
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Hatfield SD, Daniels KA, O'Donnell CL, Waggoner SN, Welsh RM. Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity. Virology. 2018 06; 519:131-144.
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Lorentsen KJ, Cho JJ, Luo X, Zuniga AN, Urban JF, Zhou L, Gharaibeh R, Jobin C, Kladde MP, Avram D. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018 04 26; 9(1):1679.
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Ricciardi MJ, Magnani DM, Grifoni A, Kwon YC, Gutman MJ, Grubaugh ND, Gangavarapu K, Sharkey M, Silveira CGT, Bailey VK, Pedreño-Lopez N, Gonzalez-Nieto L, Maxwell HS, Domingues A, Martins MA, Pham J, Weiskopf D, Altman J, Kallas EG, Andersen KG, Stevenson M, Lichtenberger P, Choe H, Whitehead SS, Sette A, Watkins DI. Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL. PLoS Negl Trop Dis. 2017 12; 11(12):e0006000.
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Carpenter SM, Yang JD, Lee J, Barreira-Silva P, Behar SM. Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis. PLoS Pathog. 2017 Nov; 13(11):e1006704.
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Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. MBio. 2017 10 24; 8(5).
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Platt CD, Fried AJ, Hoyos-Bachiloglu R, Usmani GN, Schmidt B, Whangbo J, Chiarle R, Chou J, Geha RS. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 10; 183:142-144.
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Swain SL, Kugler-Umana O, Kuang Y, Zhang W. The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age. Cell Immunol. 2017 Nov; 321:52-60.
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