CD4-Positive T-Lymphocytes

"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Descriptor ID	D015496
MeSH Number(s)	A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
Concept/Terms	CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4 Positive T Lymphocytes CD4-Positive T-Lymphocyte T-Lymphocyte, CD4-Positive T-Lymphocytes, CD4-Positive CD4-Positive Lymphocytes CD4-Positive Lymphocyte Lymphocyte, CD4-Positive Lymphocytes, CD4-Positive T4 Cells T4 Cell T4 Lymphocytes T4 Lymphocyte

Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]

Below are MeSH descriptors whose meaning is related to "CD4-Positive T-Lymphocytes".

Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.

Bar chart showing 429 publications over 31 distinct years, with a maximum of 28 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	5	5	10
1994	7	5	12
1995	3	4	7
1996	5	4	9
1997	7	2	9
1998	4	3	7
1999	3	2	5
2000	7	3	10
2001	1	9	10
2002	5	2	7
2003	10	3	13
2004	10	4	14
2005	14	8	22
2006	10	12	22
2007	12	15	27
2008	15	11	26
2009	10	9	19
2010	13	5	18
2011	11	7	18
2012	18	10	28
2013	15	8	23
2014	9	7	16
2015	8	8	16
2016	8	5	13
2017	6	4	10
2018	8	6	14
2019	6	6	12
2020	3	6	9
2021	5	6	11
2022	0	5	5
2023	2	5	7

Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.

Becerra-Artiles A, Nanaware PP, Muneeruddin K, Weaver GC, Shaffer SA, Calvo-Calle JM, Stern LJ. Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2. PLoS Pathog. 2023 07; 19(7):e1011032.

View in: PubMed
Jones MC, Castonguay C, Nanaware PP, Weaver GC, Stadinski B, Kugler-Umana OA, Huseby ES, Stern LJ, McKinstry KK, Strutt TM, Devarajan P, Swain SL. CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated. J Immunol. 2023 06 15; 210(12):1950-1961.

View in: PubMed
Gressier E, Schulte-Schrepping J, Petrov L, Brumhard S, Stubbemann P, Hiller A, Obermayer B, Spitzer J, Kostevc T, Whitney PG, Bachem A, Odainic A, van de Sandt C, Nguyen THO, Ashhurst T, Wilson K, Oates CVL, Gearing LJ, Meischel T, Hochheiser K, Greyer M, Clarke M, Kreutzenbeck M, Gabriel SS, Kastenm?ller W, Kurts C, Londrigan SL, Kallies A, Kedzierska K, Hertzog PJ, Latz E, Chen YE, Radford KJ, Chopin M, Schroeder J, Kurth F, Gebhardt T, Sander LE, Sawitzki B, Schultze JL, Schmidt SV, Bedoui S. CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity. Nat Immunol. 2023 06; 24(6):979-990.

View in: PubMed
Mohan D, Sherman HL, Mitra A, Lawlor R, Shanthalingam S, Ullom J, Pobezinskaya EL, Zhang G, Osborne BA, Pobezinsky LA, Tew GN, Minter LM. LKB1 isoform expression modulates T cell plasticity downstream of PKC? and IL-6. Mol Immunol. 2023 05; 157:129-141.

View in: PubMed
Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 04 01; 210(7):935-946.

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Stadinski BD, Cleveland SB, Brehm MA, Greiner DL, Huseby PG, Huseby ES. I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes. Nat Immunol. 2023 04; 24(4):652-663.

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Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA. Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes. Diabetes. 2023 01 01; 72(1):85-96.

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Becerra-Artiles A, Calvo-Calle JM, Co MD, Nanaware PP, Cruz J, Weaver GC, Lu L, Forconi C, Finberg RW, Moormann AM, Stern LJ. Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles. Cell Rep. 2022 06 14; 39(11):110952.

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Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J, Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker LJ, Cameron CM, Henrich TJ, Okoye AA. Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy. J Clin Invest. 2022 05 16; 132(10).

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Dhume K, Finn CM, Devarajan P, Singh A, Tejero JD, Prokop E, Strutt TM, Sell S, Swain SL, McKinstry KK. Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza. J Immunol. 2022 04 15; 208(8):1998-2007.

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