Spectrometry, Mass, Secondary Ion
"Spectrometry, Mass, Secondary Ion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.
Descriptor ID |
D018629
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MeSH Number(s) |
E05.196.566.760
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Concept/Terms |
Spectrometry, Mass, Secondary Ion- Spectrometry, Mass, Secondary Ion
- Secondary Ion Mass Spectroscopy Microscopy
- Mass Spectrometry, Secondary Ion
- Secondary Ion Mass Spectrometry
- SIMS Microscopy
- Secondary Ion Mass Spectroscopy
- Mass Spectroscopy, Secondary Ion
- Spectroscopy, Mass, Secondary Ion
- Secondary Ion Mass Spectrometry Microscopy
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Below are MeSH descriptors whose meaning is more general than "Spectrometry, Mass, Secondary Ion".
Below are MeSH descriptors whose meaning is more specific than "Spectrometry, Mass, Secondary Ion".
This graph shows the total number of publications written about "Spectrometry, Mass, Secondary Ion" by people in this website by year, and whether "Spectrometry, Mass, Secondary Ion" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 4 | 4 |
1998 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spectrometry, Mass, Secondary Ion" by people in Profiles.
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Gorman BL, Brunet MA, Pham SN, Kraft ML. Measurement of Absolute Concentration at the Subcellular Scale. ACS Nano. 2020 06 23; 14(6):6414-6419.
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Gorman BL, Kraft ML. High-Resolution Secondary Ion Mass Spectrometry Analysis of Cell Membranes. Anal Chem. 2020 01 21; 92(2):1645-1652.
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Mirshafiee V, Harley BAC, Kraft ML. Visualizing Intrapopulation Hematopoietic Cell Heterogeneity with Self-Organizing Maps of SIMS Data. Tissue Eng Part C Methods. 2018 06; 24(6):322-330.
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Yeager AN, Weber PK, Kraft ML. Cholesterol is enriched in the sphingolipid patches on the substrate near nonpolarized MDCK cells, but not in the sphingolipid domains in their plasma membranes. Biochim Biophys Acta Biomembr. 2018 10; 1860(10):2004-2011.
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Chini CE, Fisher GL, Johnson B, Tamkun MM, Kraft ML. Observation of endoplasmic reticulum tubules via TOF-SIMS tandem mass spectrometry imaging of transfected cells. Biointerphases. 2018 02 26; 13(3):03B409.
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Yeager AN, Weber PK, Kraft ML. Three-dimensional imaging of cholesterol and sphingolipids within a Madin-Darby canine kidney cell. Biointerphases. 2016 Jun 08; 11(2):02A309.
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Ilin Y, Kraft ML. Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications. Curr Opin Biotechnol. 2015 Feb; 31:108-16.
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Kraft ML, Klitzing HA. Imaging lipids with secondary ion mass spectrometry. Biochim Biophys Acta. 2014 Aug; 1841(8):1108-19.
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Frisz JF, Lou K, Klitzing HA, Hanafin WP, Lizunov V, Wilson RL, Carpenter KJ, Kim R, Hutcheon ID, Zimmerberg J, Weber PK, Kraft ML. Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E613-22.
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Klitzing HA, Weber PK, Kraft ML. Secondary ion mass spectrometry imaging of biological membranes at high spatial resolution. Methods Mol Biol. 2013; 950:483-501.