Digoxin

"Digoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Descriptor ID	D004077
MeSH Number(s)	D04.210.500.155.580.130.500.436 D04.210.500.155.580.130.688 D09.408.180.261.436
Concept/Terms	Digoxin Digoxin Lanacordin Lanacordin Lanicor Lanicor Lanoxicaps Lanoxicaps Dilanacin Dilanacin Digacin Digacin Digitek Digitek Digoregen Digoregen Digoxina Boehringer Digoxina Boehringer Boehringer, Digoxina Digoxine Nativelle Digoxine Nativelle Nativelle, Digoxine Hemigoxine Nativelle Nativelle, Hemigoxine Mapluxin Mapluxin Lanoxin Lanoxin Lanoxin-PG Lanoxin PG Lenoxin

Below are MeSH descriptors whose meaning is more general than "Digoxin".

Chemicals and Drugs [D]
Polycyclic Compounds [D04]
Fused-Ring Compounds [D04.210]
Steroids [D04.210.500]
Cardanolides [D04.210.500.155]
Cardiac Glycosides [D04.210.500.155.580]
Cardenolides [D04.210.500.155.580.130]
Digitalis Glycosides [D04.210.500.155.580.130.500]
Digoxin [D04.210.500.155.580.130.500.436]
Digoxin [D04.210.500.155.580.130.688]
Carbohydrates [D09]
Glycosides [D09.408]
Cardiac Glycosides [D09.408.180]
Digitalis Glycosides [D09.408.180.261]
Digoxin [D09.408.180.261.436]

Below are MeSH descriptors whose meaning is related to "Digoxin".

Below are MeSH descriptors whose meaning is more specific than "Digoxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Digoxin" by people in this website by year, and whether "Digoxin" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 4 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2000	2	0	2
2004	0	1	1
2008	0	1	1
2012	0	1	1
2015	1	0	1
2016	2	2	4
2020	0	1	1
2021	1	0	1

Below are the most recent publications written about "Digoxin" by people in Profiles.

Stewart JM, Warsy IA, Visintainer P, Terilli C, Medow MS. Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin. Hypertension. 2021 04; 77(4):1234-1244.

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Bosch NA, Rucci JM, Massaro JM, Winter MR, Quinn EK, Chon KH, McManus DD, Walkey AJ. Comparative Effectiveness of Heart Rate Control Medications for the Treatment of Sepsis-Associated Atrial Fibrillation. Chest. 2021 04; 159(4):1452-1459.

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Al-Khateeb M, Qureshi WT, Odeh R, Ahmed AM, Sakr S, Elshawi R, Bdeir MB, Al-Mallah MH. The impact of digoxin on mortality in patients with chronic systolic heart failure: A propensity-matched cohort study. Int J Cardiol. 2017 Feb 01; 228:214-218.

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Chiu DK, Xu IM, Lai RK, Tse AP, Wei LL, Koh HY, Li LL, Lee D, Lo RC, Wong CM, Ng IO, Wong CC. Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26. Hepatology. 2016 09; 64(3):797-813.

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Qureshi W, O'Neal WT, Soliman EZ, Al-Mallah MH. Systematic review and meta-analysis of mortality and digoxin use in atrial fibrillation. Cardiol J. 2016; 23(3):333-43.

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Hu JJ, Yin Z, Shen WL, Xie YB, Zhu T, Lu P, Cai YZ, Kong MJ, Heng BC, Zhou YT, Chen WS, Chen X, Ouyang HW. Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment. Stem Cells. 2016 Apr; 34(4):1083-96.

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Temtanakitpaisan Y, Kilari S, Damrongwatanasuk R. Use of digoxin in chronic systolic heart failure in current era. Am J Med. 2015 Jan; 128(1):e17.

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Sanghavi DM. A novel method of fetal cardioversion. Pediatr Cardiol. 2013 Mar; 34(3):700-1.

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Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing ROR?t activity. Nature. 2011 Apr 28; 472(7344):486-90.

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Leonard CE, Haynes K, Localio AR, Hennessy S, Tjia J, Cohen A, Kimmel SE, Feldman HI, Metlay JP. Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events. J Clin Epidemiol. 2008 Jun; 61(6):561-71.

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