 Propylthiouracil
"Propylthiouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
| Descriptor ID |
D011441
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| MeSH Number(s) |
D03.383.742.698.875.842.708
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Propylthiouracil".
Below are MeSH descriptors whose meaning is more specific than "Propylthiouracil".
This graph shows the total number of publications written about "Propylthiouracil" by people in this website by year, and whether "Propylthiouracil" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Propylthiouracil" by people in Profiles.
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Bansal R, Tighe D, Danai A, Rawn DF, Gaertner DW, Arnold DL, Gilbert ME, Zoeller RT. Polybrominated diphenyl ether (DE-71) interferes with thyroid hormone action independent of effects on circulating levels of thyroid hormone in male rats. Endocrinology. 2014 Oct; 155(10):4104-12.
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Sharlin DS, Gilbert ME, Taylor MA, Ferguson DC, Zoeller RT. The nature of the compensatory response to low thyroid hormone in the developing brain. J Neuroendocrinol. 2010 Mar; 22(3):153-65.
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Zoeller RT, Crofton KM. Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil. Crit Rev Toxicol. 2005 Oct-Nov; 35(8-9):771-81.
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Dowling AL, Iannacone EA, Zoeller RT. Maternal hypothyroidism selectively affects the expression of neuroendocrine-specific protein A messenger ribonucleic acid in the proliferative zone of the fetal rat brain cortex. Endocrinology. 2001 Jan; 142(1):390-9.
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Koller KJ, Wolff RS, Warden MK, Zoeller RT. Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci U S A. 1987 Oct; 84(20):7329-33.
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Rajatanavin R, Safran M, Stoller WA, Mordes JP, Braverman LE. Five patients with iodine-induced hyperthyroidism. Am J Med. 1984 Aug; 77(2):378-84.
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Reiter EO, Root AW, Rettig K, Vargas A. Childhood thyromegaly: recent developments. J Pediatr. 1981 Oct; 99(4):507-18.
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Mitsuma T, Owens R, Shenkman L, Reiter E, Hollander CS. T3 toxicosis in childhood: hyperthyroidism due to isolated hypersecretion of triiodothyronine. J Pediatr. 1972 Nov; 81(5):982-4.
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