HIV Envelope Protein gp41

"HIV Envelope Protein gp41" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by IMMUNOBLOTTING.

Descriptor ID	D015700
MeSH Number(s)	D12.776.543.512.500.330 D12.776.964.775.325.164.200 D12.776.964.775.562.500.200 D12.776.964.970.880.325.164.200 D12.776.964.970.880.910.330 D23.050.327.520.330
Concept/Terms	HIV Envelope Protein gp41 HIV Envelope Protein gp41 Envelope Protein gp41, HIV HTLV-III gp41 gp41(HIV) HIV Transmembrane Protein gp41 env Protein gp41, HIV gp41 Envelope Protein, HIV

Below are MeSH descriptors whose meaning is more general than "HIV Envelope Protein gp41".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Membrane Fusion Proteins [D12.776.543.512]
Viral Fusion Proteins [D12.776.543.512.500]
HIV Envelope Protein gp41 [D12.776.543.512.500.330]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, env [D12.776.964.775.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.325.164]
HIV Envelope Protein gp41 [D12.776.964.775.325.164.200]
Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.500]
HIV Envelope Protein gp41 [D12.776.964.775.562.500.200]
Viral Structural Proteins [D12.776.964.970]
Viral Envelope Proteins [D12.776.964.970.880]
Gene Products, env [D12.776.964.970.880.325]
env Gene Products, Human Immunodeficiency Virus [D12.776.964.970.880.325.164]
HIV Envelope Protein gp41 [D12.776.964.970.880.325.164.200]
Viral Fusion Proteins [D12.776.964.970.880.910]
HIV Envelope Protein gp41 [D12.776.964.970.880.910.330]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Viral [D23.050.327]
HIV Antigens [D23.050.327.520]
HIV Envelope Protein gp41 [D23.050.327.520.330]

Below are MeSH descriptors whose meaning is related to "HIV Envelope Protein gp41".

Below are MeSH descriptors whose meaning is more specific than "HIV Envelope Protein gp41".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HIV Envelope Protein gp41" by people in this website by year, and whether "HIV Envelope Protein gp41" was a major or minor topic of these publications.

Bar chart showing 24 publications over 17 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	1	0	1
2001	1	1	2
2003	0	1	1
2004	1	0	1
2005	1	1	2
2007	1	0	1
2008	1	0	1
2011	1	1	2
2012	1	0	1
2014	1	1	2
2015	2	1	3
2016	0	1	1
2017	1	0	1
2020	2	0	2
2021	0	1	1
2025	0	1	1

Below are the most recent publications written about "HIV Envelope Protein gp41" by people in Profiles.

Olety B, Usami Y, Peters P, Wu Y, G?ttlinger H. The ectodomain sheddase ADAM10 restricts HIV-1 propagation and is counteracted by Nef. Sci Adv. 2025 Apr 18; 11(16):eadt1836.

View in: PubMed
Duggan NN, Weisgrau KL, Magnani DM, Rakasz EG, Desrosiers RC, Martinez-Navio JM. SOSIP Trimer-Specific Antibodies Isolated from a Simian-Human Immunodeficiency Virus-Infected Monkey with versus without a Pre-blocking Step with gp41. J Virol. 2022 01 26; 96(2):e0158221.

View in: PubMed
McManus M, Karalius B, Patel K, Persaud D, Luzuriaga K. Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations. AIDS. 2020 07 01; 34(8):1117-1126.

View in: PubMed
Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 05; 16(5):e1008577.

View in: PubMed
Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10).

View in: PubMed
Yu X, Duval M, Gawron M, Posner MR, Cavacini LA. Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition. J Immunol Res. 2016; 2016:9425172.

View in: PubMed
Jiang X, Feyertag F, Meehan CJ, McCormack GP, Travers SA, Craig C, Westby M, Lewis M, Robertson DL. Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor. J Virol. 2015 Nov; 89(22):11457-72.

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Durham ND, Chen BK. HIV-1 Cell-Free and Cell-to-Cell Infections Are Differentially Regulated by Distinct Determinants in the Env gp41 Cytoplasmic Tail. J Virol. 2015 Sep; 89(18):9324-37.

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Munro JB, Mothes W. Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 89(11):5752-5.

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Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-61.

View in: PubMed

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