Spike Glycoprotein, Coronavirus

"Spike Glycoprotein, Coronavirus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.

Descriptor ID	D064370
MeSH Number(s)	D12.776.543.512.500.665 D12.776.964.970.880.910.665
Concept/Terms	Spike Glycoprotein, Coronavirus Spike Glycoprotein, Coronavirus Coronavirus Spike Glycoprotein Spike Protein, Coronavirus Coronavirus Spike Protein Glycoprotein S, Coronavirus Spike Glycoproteins, Coronavirus Spike Glycoprotein S1, Coronavirus Spike Glycoprotein S1, Coronavirus Spike Gp S1, Cor Spike Protein S2, Coronavirus Spike Protein S2, Coronavirus E2 Spike Glycoprotein, Coronavirus

Below are MeSH descriptors whose meaning is more general than "Spike Glycoprotein, Coronavirus".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Membrane Fusion Proteins [D12.776.543.512]
Viral Fusion Proteins [D12.776.543.512.500]
Spike Glycoprotein, Coronavirus [D12.776.543.512.500.665]
Viral Proteins [D12.776.964]
Viral Structural Proteins [D12.776.964.970]
Viral Envelope Proteins [D12.776.964.970.880]
Viral Fusion Proteins [D12.776.964.970.880.910]
Spike Glycoprotein, Coronavirus [D12.776.964.970.880.910.665]

Below are MeSH descriptors whose meaning is related to "Spike Glycoprotein, Coronavirus".

Below are MeSH descriptors whose meaning is more specific than "Spike Glycoprotein, Coronavirus".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spike Glycoprotein, Coronavirus" by people in this website by year, and whether "Spike Glycoprotein, Coronavirus" was a major or minor topic of these publications.

Bar chart showing 71 publications over 14 distinct years, with a maximum of 19 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	1	1
2005	0	4	4
2008	0	1	1
2009	0	3	3
2010	0	1	1
2011	0	1	1
2012	0	1	1
2020	5	3	8
2021	7	9	16
2022	5	14	19
2023	1	6	7
2024	3	2	5
2025	2	1	3

Below are the most recent publications written about "Spike Glycoprotein, Coronavirus" by people in Profiles.

Matsuda K, Harrison M, Wettstein E, Pederson J, Pullano AA, Bolkhovitinov L, Kim B, Steinberg I, Griesman T, Stuccio S, Rogan D, Patamawenu A, Shofner T, Wright NE, Webber JD, Van't Veer F, Roenicke R, Koory E, Roeder PM, Ober E, Leach B, Tsybovsky Y, Stephens T, Del Moral-Sanchez I, Bontjer I, McGinnes-Cullen LW, Chu E, Liang J, Torres JL, Lin RN, Tran AS, Dziubla G, Serebryannyy L, Narpala S, Lin B, Castro M, Ozorowski G, Ward AB, Sanders RW, Kwong PD, Guenaga J, Wyatt R, Morrison T, Connors M. Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response. Nat Commun. 2025 Jun 03; 16(1):5162.

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Du Y, Yang Y, Nguyen SN, Kaltashov IA. The Role of Long-Range Non-Specific Electrostatic Interactions in Inhibiting the Pre-Fusion Proteolytic Processing of the SARS-CoV-2 S Glycoprotein by Heparin. Biomolecules. 2025 May 28; 15(6).

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Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS. Computationally designed proteins mimic antibody immune evasion in viral evolution. Immunity. 2025 Jun 10; 58(6):1411-1421.e6.

View in: PubMed
Hojo-Souza NS, de Castro JT, Rivelli GG, Azevedo PO, Oliveira ER, Faustino LP, Salazar N, Bagno FF, Carvalho AF, Rattis B, Louren?o KL, Gomes IP, Assis BRD, Piccin M, Fonseca FG, Durigon E, Silva JS, de Souza RP, Goulart GAC, Santiago H, Fernandes APS, Teixeira SR, Gazzinelli RT. SpiN-Tec: A T cell-based recombinant vaccine that is safe, immunogenic, and shows high efficacy in experimental models challenged with SARS-CoV-2 variants of concern. Vaccine. 2024 12 02; 42(26):126394.

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Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 11 07; 32(11):1910-1925.e6.

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D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 07 19; 10(29):eadk4920.

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Kushwaha N, Dwivedi A, Tiwari S, Mishra P, Verma SK. Comprehensive analytics for virus-cell and cell-cell multinucleation system. Biochem Biophys Res Commun. 2024 09 24; 726:150281.

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Baker R, Lawlor R, Smith M, Price J, Eaton A, Lover A, Alfandari D, Reinhart P, Arcaro KF, Osborne BA. Antibody responses in blood and saliva post COVID-19 bivalent booster do not reveal an Omicron BA.4/BA.5- specific response. Front Immunol. 2024; 15:1401209.

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Alsaiari SK, Nadeef S, Daristotle JL, Rothwell W, Du B, Garcia J, Zhang L, Sarmadi M, Forster TA, Menon N, Lin SQ, Tostanoski LH, Hachmann N, Wang EY, Ventura JD, Barouch DH, Langer R, Jaklenec A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci Adv. 2024 03 08; 10(10):eadj6380.

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Yao W, Li Y, Ma D, Hou X, Wang H, Tang X, Cheng D, Zhang H, Du C, Pan H, Li C, Lin H, Sun M, Ding Q, Wang Y, Gao J, Zhong G. Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs. Microbiol Spectr. 2023 Dec 12; 11(6):e0267623.

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