Spike Glycoprotein, Coronavirus

"Spike Glycoprotein, Coronavirus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.

Descriptor ID	D064370
MeSH Number(s)	D12.776.543.512.500.665 D12.776.964.970.880.910.665
Concept/Terms	Spike Glycoprotein, Coronavirus Spike Glycoprotein, Coronavirus Coronavirus Spike Glycoprotein Spike Protein, Coronavirus Coronavirus Spike Protein Glycoprotein S, Coronavirus Spike Glycoproteins, Coronavirus Spike Glycoprotein S1, Coronavirus Spike Glycoprotein S1, Coronavirus Spike Gp S1, Cor Spike Protein S2, Coronavirus Spike Protein S2, Coronavirus E2 Spike Glycoprotein, Coronavirus

Below are MeSH descriptors whose meaning is more general than "Spike Glycoprotein, Coronavirus".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Membrane Fusion Proteins [D12.776.543.512]
Viral Fusion Proteins [D12.776.543.512.500]
Spike Glycoprotein, Coronavirus [D12.776.543.512.500.665]
Viral Proteins [D12.776.964]
Viral Structural Proteins [D12.776.964.970]
Viral Envelope Proteins [D12.776.964.970.880]
Viral Fusion Proteins [D12.776.964.970.880.910]
Spike Glycoprotein, Coronavirus [D12.776.964.970.880.910.665]

Below are MeSH descriptors whose meaning is related to "Spike Glycoprotein, Coronavirus".

Below are MeSH descriptors whose meaning is more specific than "Spike Glycoprotein, Coronavirus".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spike Glycoprotein, Coronavirus" by people in this website by year, and whether "Spike Glycoprotein, Coronavirus" was a major or minor topic of these publications.

Bar chart showing 54 publications over 13 distinct years, with a maximum of 12 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	1	1
2005	0	4	4
2008	0	1	1
2009	0	3	3
2010	0	1	1
2011	0	1	1
2012	0	1	1
2020	6	3	9
2021	4	6	10
2022	3	9	12
2023	0	4	4
2024	3	3	6

Below are the most recent publications written about "Spike Glycoprotein, Coronavirus" by people in Profiles.

Hojo-Souza NS, de Castro JT, Rivelli GG, Azevedo PO, Oliveira ER, Faustino LP, Salazar N, Bagno FF, Carvalho AF, Rattis B, Louren?o KL, Gomes IP, Assis BRD, Piccin M, Fonseca FG, Durigon E, Silva JS, de Souza RP, Goulart GAC, Santiago H, Fernandes APS, Teixeira SR, Gazzinelli RT. SpiN-Tec: A T cell-based recombinant vaccine that is safe, immunogenic, and shows high efficacy in experimental models challenged with SARS-CoV-2 variants of concern. Vaccine. 2024 Dec 02; 42(26):126394.

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Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 Nov 07; 32(11):1910-1925.e6.

View in: PubMed
D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 Jul 19; 10(29):eadk4920.

View in: PubMed
Kushwaha N, Dwivedi A, Tiwari S, Mishra P, Verma SK. Comprehensive analytics for virus-cell and cell-cell multinucleation system. Biochem Biophys Res Commun. 2024 09 24; 726:150281.

View in: PubMed
Baker R, Lawlor R, Smith M, Price J, Eaton A, Lover A, Alfandari D, Reinhart P, Arcaro KF, Osborne BA. Antibody responses in blood and saliva post COVID-19 bivalent booster do not reveal an Omicron BA.4/BA.5- specific response. Front Immunol. 2024; 15:1401209.

View in: PubMed
Alsaiari SK, Nadeef S, Daristotle JL, Rothwell W, Du B, Garcia J, Zhang L, Sarmadi M, Forster TA, Menon N, Lin SQ, Tostanoski LH, Hachmann N, Wang EY, Ventura JD, Barouch DH, Langer R, Jaklenec A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci Adv. 2024 Mar 08; 10(10):eadj6380.

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Becerra-Artiles A, Nanaware PP, Muneeruddin K, Weaver GC, Shaffer SA, Calvo-Calle JM, Stern LJ. Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2. PLoS Pathog. 2023 07; 19(7):e1011032.

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Chen C, Zhu R, Hodge EA, D?az-Salinas MA, Nguyen A, Munro JB, Lee KK. hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics. ACS Infect Dis. 2023 06 09; 9(6):1180-1189.

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Egri SB, Wang X, D?az-Salinas MA, Luban J, Dudkina NV, Munro JB, Shen K. Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination. Nat Commun. 2023 05 03; 14(1):2527.

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Binder RA, Fujimori GF, Forconi CS, Reed GW, Silva LS, Lakshmi PS, Higgins A, Cincotta L, Dutta P, Salive MC, Mangolds V, Anya O, Calvo Calle JM, Nixon T, Tang Q, Wessolossky M, Wang Y, Ritacco DA, Bly CS, Fischinger S, Atyeo C, Oluoch PO, Odwar B, Bailey JA, Maldonado-Contreras A, Haran JP, Schmidt AG, Cavacini L, Alter G, Moormann AM. SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome. J Infect Dis. 2023 02 01; 227(3):371-380.

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