"Syndecans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with heparin sulfate and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS and may play a role in modulating cellular signaling during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis.
Descriptor ID |
D053667
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MeSH Number(s) |
D12.776.395.550.847 D12.776.395.650.350.500 D12.776.543.550.847
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Syndecans".
Below are MeSH descriptors whose meaning is more specific than "Syndecans".
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Below are the most recent publications written about "Syndecans" by people in Profiles.
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Lambaerts K, Wilcox-Adelman SA, Zimmermann P. The signaling mechanisms of syndecan heparan sulfate proteoglycans. Curr Opin Cell Biol. 2009 Oct; 21(5):662-9.