A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

Descriptor ID	D019699
MeSH Number(s)	D12.776.395.550.895 D12.776.543.550.895
Concept/Terms	Thrombospondins Thrombospondins Thrombospondin

Below are MeSH descriptors whose meaning is more general than "Thrombospondins".

Below are MeSH descriptors whose meaning is related to "Thrombospondins".

Below are MeSH descriptors whose meaning is more specific than "Thrombospondins".