Galectins

"Galectins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.

Descriptor ID	D037161
MeSH Number(s)	D12.776.503.307
Concept/Terms	Galectins Galectins beta-Galactoside Binding Lectin Binding Lectin, beta-Galactoside Lectin, beta-Galactoside Binding beta Galactoside Binding Lectin D-Galactoside-Binding Lectin D Galactoside Binding Lectin Lectin, D-Galactoside-Binding S-Type Lectins S Type Lectins Galaptins Galectin Lectins, S-Type Lectins, S Type S-Type Lectin Lectin, S-Type S Type Lectin beta-D-Galactosyl-Specific Lectin Lectin, beta-D-Galactosyl-Specific beta D Galactosyl Specific Lectin Galactose-Binding Lectin Galactose Binding Lectin Lectin, Galactose-Binding beta-D-Gal(1-3)D-GalNAc Specific Lectins beta-D-Gal(1-3)D-GalNAc Specific Lectins

Below are MeSH descriptors whose meaning is more general than "Galectins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Lectins [D12.776.503]
Galectins [D12.776.503.307]

Below are MeSH descriptors whose meaning is related to "Galectins".

Below are MeSH descriptors whose meaning is more specific than "Galectins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Galectins" by people in this website by year, and whether "Galectins" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2010	1	0	1
2011	1	0	1
2012	1	1	2
2013	0	1	1
2018	1	0	1
2025	1	0	1

Below are the most recent publications written about "Galectins" by people in Profiles.

Baran A, Nowowiejska J, Parzych J, Hermanowicz JM, Sieklucka B, Pawlak D, Flisiak I. Plasma Galectin-4 and Charcot-Leyden Crystal Protein/Galectin-10 as Emerging Biomarkers of Metabolically Induced Inflammation in Patients with Psoriasis. Int J Mol Sci. 2025 Oct 23; 26(21).

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Rodr?guez-Alc?zar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenm?ller W, Latz E, Franklin BS. Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages. J Immunol. 2019 01 15; 202(2):550-558.

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Conrad ML, Freitag N, Diessler ME, Hernandez R, Barrientos G, Rose M, Casas LA, Barbeito CG, Blois SM. Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation. Am J Reprod Immunol. 2016 Mar; 75(3):317-25.

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Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91.

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Sada-Ovalle I, Ch?vez-Gal?n L, Torre-Bouscoulet L, Nava-Gami?o L, Barrera L, Jayaraman P, Torres-Rojas M, Salazar-Lezama MA, Behar SM. The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis. J Immunol. 2012 Dec 15; 189(12):5896-902.

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Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA. Antigen-independent induction of Tim-3 expression on human T cells by the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J Immunol. 2012 Apr 15; 188(8):3745-56.

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Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug; 32(8):345-9.

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Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med. 2010 Oct 25; 207(11):2343-54.

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Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501.

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Raabe EH, Yoshida K, Schwarting GA. Differential laminin isoform expression in the developing rat olfactory system. Brain Res Dev Brain Res. 1997 Jul 18; 101(1-2):187-96.

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