"Galectin 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.
| Descriptor ID |
D037502
|
| MeSH Number(s) |
D12.776.503.307.300
|
| Concept/Terms |
Galectin 3- Galectin 3
- CBP-30
- CBP-35
- CBP35
- Epsilon-Binding Protein
- Epsilon Binding Protein
- Galectin-3
- HL-29
- IgE Binding Protein
- Binding Protein, IgE
- Protein, IgE Binding
- IgEBP
- L-29 Lectin
- L 29 Lectin
- L-31
- L-34
- L30 Lectin
- LGALS3
- Mac-2 Antigen
- Antigen, Mac-2
- Mac 2 Antigen
- Macrophage-2 Antigen
- Antigen, Macrophage-2
- Macrophage 2 Antigen
- Carbohydrate-Binding Protein 35
- Carbohydrate Binding Protein 35
|
Below are MeSH descriptors whose meaning is more general than "Galectin 3".
Below are MeSH descriptors whose meaning is more specific than "Galectin 3".
This graph shows the total number of publications written about "Galectin 3" by people in this website by year, and whether "Galectin 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Galectin 3" by people in Profiles.
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Das A, Malley R, Bailes JE, Bobustuc GC, Varma AK, Lindhorst SM, Cachia D. Effects of Galectin-3 inhibitors paired with direct current stimulation in preclinical models of aggressive meningioma. Mol Biol Rep. 2026 Jun 27; 53(1).
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Chaudoin TR, Bonasera SJ. Mice lacking galectin-3 (Lgals3) function have decreased home cage movement. BMC Neurosci. 2018 05 02; 19(1):27.
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Feeley EM, Pilla-Moffett DM, Zwack EE, Piro AS, Finethy R, Kolb JP, Martinez J, Brodsky IE, Coers J. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1698-E1706.
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Ho JE, Yin X, Levy D, Vasan RS, Magnani JW, Ellinor PT, McManus DD, Lubitz SA, Larson MG, Benjamin EJ. Galectin 3 and incident atrial fibrillation in the community. Am Heart J. 2014 May; 167(5):729-34.e1.
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Zuberi RI, Hsu DK, Kalayci O, Chen HY, Sheldon HK, Yu L, Apgar JR, Kawakami T, Lilly CM, Liu FT. Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. Am J Pathol. 2004 Dec; 165(6):2045-53.
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Kalayci O, Birben E, Tinari N, Oguma T, Iacobelli S, Lilly CM. Role of 90K protein in asthma and TH2-type cytokine expression. Ann Allergy Asthma Immunol. 2004 Nov; 93(5):485-92.
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Lise M, Loda M, Fiorentino M, Mercurio AM, Summerhayes IC, Lavin PT, Jessup JM. Association between sucrase-isomaltase and p53 expression in colorectal cancer. Ann Surg Oncol. 1997 Mar; 4(2):176-83.
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Lotz MM, Andrews CW, Korzelius CA, Lee EC, Steele GD, Clarke A, Mercurio AM. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3466-70.
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Lee EC, Woo HJ, Korzelius CA, Steele GD, Mercurio AM. Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma. Arch Surg. 1991 Dec; 126(12):1498-502.
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Woo HJ, Lotz MM, Jung JU, Mercurio AM. Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186. J Biol Chem. 1991 Oct 05; 266(28):18419-22.