Stem Cell Niche

"Stem Cell Niche" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.

Descriptor ID	D055153
MeSH Number(s)	G04.366.249
Concept/Terms	Stem Cell Niche Stem Cell Niche Cell Niche, Stem Cell Niches, Stem Niche, Stem Cell Niches, Stem Cell Stem Cell Niches Stem Cell Microenvironment Cell Microenvironment, Stem Cell Microenvironments, Stem Microenvironment, Stem Cell Microenvironments, Stem Cell Stem Cell Microenvironments

Below are MeSH descriptors whose meaning is more general than "Stem Cell Niche".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cellular Microenvironment [G04.366]
Stem Cell Niche [G04.366.249]

Below are MeSH descriptors whose meaning is related to "Stem Cell Niche".

Below are MeSH descriptors whose meaning is more specific than "Stem Cell Niche".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Stem Cell Niche" by people in this website by year, and whether "Stem Cell Niche" was a major or minor topic of these publications.

Bar chart showing 20 publications over 12 distinct years, with a maximum of 3 publications in 2017 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	1	0	1
2010	1	0	1
2011	1	0	1
2013	1	1	2
2015	0	2	2
2016	0	1	1
2017	2	1	3
2018	1	2	3
2020	0	1	1
2021	0	2	2
2023	2	0	2
2025	1	0	1

Below are the most recent publications written about "Stem Cell Niche" by people in Profiles.

Bhattacharya S, Tie G, Singh PNP, Malagola E, Eskiocak O, He R, Kraiczy J, Gu W, Perlov Y, Alici-Garipcan A, Beyaz S, Wang TC, Zhou Q, Shivdasani RA. Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell. Cell Stem Cell. 2025 Jun 05; 32(6):952-969.e8.

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Kraiczy J, McCarthy N, Malagola E, Tie G, Madha S, Boffelli D, Wagner DE, Wang TC, Shivdasani RA. Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 04 06; 30(4):433-449.e8.

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McCarthy N, Tie G, Madha S, He R, Kraiczy J, Maglieri A, Shivdasani RA. Smooth muscle contributes to the development and function of a layered intestinal stem cell niche. Dev Cell. 2023 04 10; 58(7):550-564.e6.

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Patel SA, Dalela D, Fan AC, Lloyd MR, Zhang TY. Niche-directed therapy in acute myeloid leukemia: optimization of stem cell competition for niche occupancy. Leuk Lymphoma. 2022 01; 63(1):10-18.

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Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 03; 97:40-57.

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Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 11; 4(11):1076-1089.

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Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 02 01; 37(2):320-326.

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Sokolova OA, Mikhaleva EA, Kharitonov SL, Abramov YA, Gvozdev VA, Klenov MS. Special vulnerability of somatic niche cells to transposable element activation in Drosophila larval ovaries. Sci Rep. 2020 01 23; 10(1):1076.

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Heath JL, Cohn GM, Zaidi SK, Stein GS. The role of cell adhesion in hematopoiesis and leukemogenesis. J Cell Physiol. 2019 11; 234(11):19189-19198.

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Zhao S, Fortier TM, Baehrecke EH. Autophagy Promotes Tumor-like Stem Cell Niche Occupancy. Curr Biol. 2018 10 08; 28(19):3056-3064.e3.

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